File:Developing human cerebellum 01.jpg
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Developing Human Cerebellum
(A–X) A greater EGL cell density and reduced EGL thickness were reported in preterms with ex-utero exposure, as compared to their age matched stillborn controls. ML thickness was increased in preterms with ex-utero exposure born after 34 weeks gestation, as compared to their age matched controls. Compare E with F, G with H and I with J.
- wk = number of gestational weeks
- d = number of postnatal days
- mon PN = postnatal months - born at term
- EGL = external granular layer
- ML = molecular layer
- PL = purkinje cell layer
- IGL = internal granular layer
Cresyl violet stained sections
Scale bar = 50 µm (A–L) and 20 µm (M–X).
- "A rapid growth in human cerebellar development occurs in the third trimester, which is impeded by preterm delivery. ...We report that premature birth and development in an ex-utero environment leads to a significant decrease in the thickness and an increase in the packing density of the cells within the external granular layer and the inner granular layer well, as a reduction in the density of bergmann glial fibres. In addition, this also leads to a reduced expression of sonic hedgehog in the purkinje layer. We conclude that the developmental program of the cerebellum is specifically modified by events that follow preterm delivery."
Haldipur P, Bharti U, Alberti C, Sarkar C, Gulati G, Iyengar S, Gressens P & Mani S. (2011). Preterm delivery disrupts the developmental program of the cerebellum. PLoS ONE , 6, e23449. PMID: 21858122 DOI.
© 2011 Haldipur et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Figure 1. Journal.pone.0023449.g001.jpg
Cite this page: Hill, M.A. (2021, October 16) Embryology Developing human cerebellum 01.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Developing_human_cerebellum_01.jpg
- © Dr Mark Hill 2021, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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|current||23:21, 22 September 2011||1,009 × 1,200 (494 KB)||S8600021||==Cresyl violet stained sections of the developing human cerebellum== (A–X) A greater EGL cell density and reduced EGL thickness were reported in preterms with ex-utero exposure, as compared to their age matched stillborn controls. ML thickness was inc|