File:Cortical plate development.jpg

Cortex development in wild type and reeler mutant mice

Description

Preplate stage of cerebral cortex development. Preplate neurons are dark blue; undifferentiated ventricular zone cells are green; radial glia are purple; and Reelin, produced by Cajal-Retzius cells, is represented by light blue dots. (a) Separation of the preplate into subplate and marginal zone by the developing cortical plate in wild-type mice. Future layer VI neurons are orange; future layer V neurons are red. (b) In reeler mutant mice, the developing cortical plate fails to separate the preplate into two layers. Neurons that should become layer V (red) do not by pass the neurons that should become layer VI (yellow). In the reeler cortex, the dendritic processes are arranged in a haphazard manner, whereas the axons are mostly normal.

Reference

Original student image based upon: http://www.cell.com/current-biology/fulltext/S0960-9822(06)00108-4?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0960982206001084%3Fshowall%3Dtrue

Copyright

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