File:Chromosome segregation defects associated with abnormal spindles in UBE3A shRNA knockdown clones.jpg

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Chromosome segregation defects associated with abnormal spindles in UBE3A shRNA knockdown clones

Examples of cells attempting to divide with missegregated (clone T, anaphase) and lagging chromosomes (clone U, telophase) (arrows). Also note cells with chromosomes hanging at the equatorial plane (clone U, anaphase and clone T, telophase) (arrows). Note the cells have disorganized mitotic spindles (all four panels) and bundling of microtubules at the central spindle (clone U, telophase) and at MTOC (clone T, anaphase). Scale=2 µm.


Original file name: Figure 7 pone.0020397.g007.jpg

Reference

<pubmed>21633703</pubmed>|PMC3102111 | PLoS One


Copyright Singhmar, Kumar. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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current00:31, 17 August 2011Thumbnail for version as of 00:31, 17 August 2011484 × 456 (110 KB)Z3293267 (talk | contribs)==Chromosome segregation defects associated with abnormal spindles in UBE3A shRNA knockdown clones== Examples of cells attempting to divide with missegregated (clone T, anaphase) and lagging chromosomes (clone U, telophase) (arrows). Also note cells with

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