File:Cervical intersomitic vessels.png

Mouse - Cervical Intersomitic Vessel

A The various stages of cervical intersomitic vessel development can be segmented as visualized as surface renderings in the 16 somite mouse embryo (Theiler Stage 13 - Theiler Stage 14)

The vessels along the right side of the embryo and surrounding somites 1 through 16 are labelled as: DA (red), ISA (pink), ISV (blue), VTA (vertebral artery), DLAV (dorsal longitudinal anastomotical vessel) and PNVP (green) (perineual vascular plexus) , ACV (anterior cardinal vein) and CCV (cyan) (common cardinal vein) , UV (dark pink), UV plexus (purple), and PCV (blue). Somites 1, 5, 10 and 15 are numbered as S-1, S-5, S-10 and S-15.

B Branches of PECAM-1 expression originating from the tips of the ISAs (yellow arrowheads) were observed to turn towards the location of the future PCV (posterior cardinal vein).

C A second branch from the ISA was also observed to extend in a predominantly anterior direction (pink arrowheads) to connect up with other ISAs, eventually forming the DLAV. PECAM-1 expression along the location of the expected PCV was observed to lag development of the ISAs and is discontinuous (yellow arrowheads).

D The PNVP develops through remodelling of the VTA and DLAV. Branches initiate medially from the DLAV (pink arrowhead), begin to remodel into simple mesh (blue arrowhead), and eventually remodel into a fine structured capillary plexus surrounding the neural tube. Note at this stage that the first ISA has regressed.

Scale bars represent 100 microns.

Legend

ACV - anterior cardinal vein

CCV - common cardinal vein

DA - dorsal aorta

DLAV - dorsal longitudinal anastomotical vessel

ISA - intersomitic artery

ISV - intersomitic vein

OA - omphalomesenteric artery

OV - omphalomesenteric vein

PCV - posterior cardinal vein

PNVP - perineual vascular plexus

UA - umbilical artery

UV - umbilical vein

Original File: [http://www.plosone.org/article/slideshow.action?uri=info:doi/10.1371/journal.pone.0002853&imageURI=info:doi/10.1371/journal.pone.0002853.g009 Journal.pone.0002853.g009.png]

Reference

<pubmed>18682734</pubmed>| PLoS ONE

Copyright: © 2008 Walls et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.