Centrosome_cartoon.jpg (732 × 496 pixels, file size: 67 KB, MIME type: image/jpeg)
- Centrosome consists of two centrioles that are formed from nine sets of microtubules (red tubes), which are triplet at the proximal ends and doublet at the distal ends of centrioles.
- Human centriole cylinder - approximate diameters of 150–200 nm and lengths of 400–450 nm
- The two centrioles attached to one another via their proximal ends by a flexible linker (green ribbons).
- Surrounding the proximal ends of each centriole is a matrix of proteins, the pericentriolar material (PCM) that is a site of microtubule nucleation as well as procentriole assembly (yellow ribbons).
- The two centrioles differ from one another, as one is slightly longer and also possesses two sets of appendages (distal and sub-distal drawn as orange sticks and red cones, respectively).
- older centriole (mother) while the other is the daughter centriole.
- basal bodies form either de novo or from the oldest, platforms for the formation of motile and immotile cilia
Polo-like kinase 4 (PLK4)
- localizes to the proximal ends of both centrioles and the distal end of the mother centriole.
- unique member of the Polo-like family of kinases that shares little homology with its siblings and has an essential role in centriole duplication.
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<pubmed>20920249</pubmed>| Cell Div.
Sillibourne and Bornens Cell Division 2010 5:25 doi:10.1186/1747-1028-5-25
© 2010 Sillibourne and Bornens; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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|13:29, 15 October 2010||600 × 407 (62 KB)||S8600021||==The centrosome== The centrosome consists of two centrioles that are formed from nine sets of microtubules (red tubes), which are triplet at the proximal ends and doublet at the distal ends of centrioles. The two centrioles attached to one another via t|