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=Cell Signalling in Cerebellum Development=
=Cell Signalling in Cerebellum Development=
==Summary==
==Summary==
Purkinje cells (P) secrete the ligand Sonic Hedgehog (green triangles) which acts on the external granule layer (bright red circles) to increase mitosis and therefore proliferation, the Bergmann glia (B) to stimulate differentiation, and has an unknown effect on the purkinje cells.  Laminin and heparan sulfate positively affect this pathway and fibronectin and vitronectin negatively affect this pathway.
Purkinje cells (P) secrete the ligand Sonic Hedgehog (green triangles) which acts on the external granule layer (bright red circles) to increase mitosis and therefore proliferation, the Bergmann glia (B) to stimulate differentiation, and has an unknown effect on the purkinje cells.  Laminin and heparan sulfate positively affect this pathway and fibronectin and vitronectin negatively affect this pathway.<ref><PMID>22291620</PMID></ref>
 
==Reference==
==Reference==


==Copyright==
==Copyright==
© 2012 Manto and Jissendi. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
© 2012 Manto and Jissendi. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

Revision as of 17:29, 22 October 2017

Cell Signalling in Cerebellum Development

Summary

Purkinje cells (P) secrete the ligand Sonic Hedgehog (green triangles) which acts on the external granule layer (bright red circles) to increase mitosis and therefore proliferation, the Bergmann glia (B) to stimulate differentiation, and has an unknown effect on the purkinje cells. Laminin and heparan sulfate positively affect this pathway and fibronectin and vitronectin negatively affect this pathway.[1]

Reference

Copyright

© 2012 Manto and Jissendi. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

  1. <PMID>22291620</PMID>

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current13:50, 20 October 2017Thumbnail for version as of 13:50, 20 October 2017758 × 389 (230 KB)Z5177699 (talk | contribs)Purkinje cells (P) secrete the ligand Sonic Hedgehog (green triangles) which acts on the external granule layer (bright red circles) to increase mitosis and therefore proliferation, the Bergmann glia (B) to stimulate differentiation, and has an unknown...

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