File:Blood-brain barrier cartoon.jpg: Difference between revisions
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* '''pericytes''' - (Rouget cells) cells located at the abluminal surface of microvessels close to endothelial cells, mainly found associated with CNS vessels and involved in vessel formation, remodeling and stabilization. | * '''pericytes''' - (Rouget cells) cells located at the abluminal surface of microvessels close to endothelial cells, mainly found associated with CNS vessels and involved in vessel formation, remodeling and stabilization. | ||
:'''Links:''' | :'''Links:''' [[Neural - Vascular Development]] | ||
===Reference=== | ===Reference=== | ||
<pubmed>28484368</pubmed> | <pubmed>28484368</pubmed> | ||
Revision as of 10:21, 27 May 2017
Neurovascular unit (NVU)
A layer of brain endothelial cells connected by tight junctions forms the blood-brain barrier (BBB). The intimate contact of these specialized endothelial cells with different cell types constitutes the NVU.
A basement membrane embeds the brain endothelial cells, the pericytes, and astrocytes.
In areas where the basement membrane is absent, brain endothelial cells and pericytes connect through peg-socket junctions.
Astrocytes extend its end-feet and establish a close interaction with endothelial cells through transmembrane proteins, such as aquaporins. Astrocytes also connect with pericytes and neurons and together regulate BBB maintenance and function. The interaction of the cell components of the NVU with neurons and microglia can influence barrier function.
- pericytes - (Rouget cells) cells located at the abluminal surface of microvessels close to endothelial cells, mainly found associated with CNS vessels and involved in vessel formation, remodeling and stabilization.
Reference
<pubmed>28484368</pubmed>
Development and Function of the Blood-Brain Barrier in the Context of Metabolic Control. Haddad-Tóvolli R, Dragano NRV, Ramalho AFS, Velloso LA. Front Neurosci. 2017 Apr 21;11:224. doi: 10.3389/fnins.2017.00224. eCollection 2017. Review. PMID: 28484368 http://journal.frontiersin.org/article/10.3389/fnins.2017.00224/full
Copyright
© 2017 Haddad-Tóvolli, Dragano, Ramalho and Velloso. This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Cite this page: Hill, M.A. (2024, April 23) Embryology Blood-brain barrier cartoon.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Blood-brain_barrier_cartoon.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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| 10:04, 27 May 2017 |  | 1,013 × 1,765 (238 KB) | Z8600021 (talk | contribs) | ==Neurovascular unit (NVU)== A layer of brain endothelial cells connected by tight junctions forms the blood-brain barrier. The intimate contact of these specialized endothelial cells with different cell types constitutes the NVU. A basement membrane... |
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