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==Neurovascular unit (NVU)==
==Neurovascular unit (NVU)==


A layer of brain endothelial
A layer of brain endothelial cells connected by tight junctions forms the blood-brain barrier (BBB). The intimate contact of these specialized endothelial cells with different cell types constitutes the NVU.  
cells connected by tight junctions forms the blood-brain barrier. The intimate contact of these specialized endothelial cells with different cell types constitutes the NVU. A basement membrane embeds the brain endothelial cells, the pericytes, and astrocytes. In areas where the basement membrane is absent, brain endothelial cells and pericytes connect through peg-socket junctions. Astrocytes extend its end-feet and establish a close interaction with endothelial cells through transmembrane proteins, such as aquaporins. Astrocytes also connect with pericytes and neurons and together regulate BBB maintenance and function. The interaction of the cell components of the NVU with neurons and microglia can influence barrier function.
 
A basement membrane embeds the brain endothelial cells, the pericytes, and astrocytes.  
 
In areas where the basement membrane is absent, brain endothelial cells and pericytes connect through peg-socket junctions.  
 
Astrocytes extend its end-feet and establish a close interaction with endothelial cells through transmembrane proteins, such as aquaporins. Astrocytes also connect with pericytes and neurons and together regulate BBB maintenance and function. The interaction of the cell components of the NVU with neurons and microglia can influence barrier function.
 
 
===Reference===
===Reference===
<pubmed>28484368</pubmed>
<pubmed>28484368</pubmed>
Development and Function of the Blood-Brain Barrier in the Context of Metabolic Control. Haddad-Tóvolli R, Dragano NRV, Ramalho AFS, Velloso LA. Front Neurosci. 2017 Apr 21;11:224. doi: 10.3389/fnins.2017.00224. eCollection 2017. Review. [https://www.ncbi.nlm.nih.gov/pubmed/28484368 PMID: 28484368] http://journal.frontiersin.org/article/10.3389/fnins.2017.00224/full
====Copyright====
====Copyright====
© 2017 Haddad-Tóvolli, Dragano, Ramalho and Velloso. This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
© 2017 Haddad-Tóvolli, Dragano, Ramalho and Velloso. This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.


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[[Category:Cartoon]][[Category:Cardiovascular]][[Category:Neural]]

Revision as of 11:08, 27 May 2017

Neurovascular unit (NVU)

A layer of brain endothelial cells connected by tight junctions forms the blood-brain barrier (BBB). The intimate contact of these specialized endothelial cells with different cell types constitutes the NVU.

A basement membrane embeds the brain endothelial cells, the pericytes, and astrocytes.

In areas where the basement membrane is absent, brain endothelial cells and pericytes connect through peg-socket junctions.

Astrocytes extend its end-feet and establish a close interaction with endothelial cells through transmembrane proteins, such as aquaporins. Astrocytes also connect with pericytes and neurons and together regulate BBB maintenance and function. The interaction of the cell components of the NVU with neurons and microglia can influence barrier function.


Reference

<pubmed>28484368</pubmed>

Development and Function of the Blood-Brain Barrier in the Context of Metabolic Control. Haddad-Tóvolli R, Dragano NRV, Ramalho AFS, Velloso LA. Front Neurosci. 2017 Apr 21;11:224. doi: 10.3389/fnins.2017.00224. eCollection 2017. Review. PMID: 28484368 http://journal.frontiersin.org/article/10.3389/fnins.2017.00224/full

Copyright

© 2017 Haddad-Tóvolli, Dragano, Ramalho and Velloso. This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.


Cite this page: Hill, M.A. (2024, March 29) Embryology Blood-brain barrier cartoon.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Blood-brain_barrier_cartoon.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current11:05, 27 May 2017Thumbnail for version as of 11:05, 27 May 2017765 × 1,000 (75 KB)Z8600021 (talk | contribs)
11:04, 27 May 2017Thumbnail for version as of 11:04, 27 May 20171,013 × 1,765 (238 KB)Z8600021 (talk | contribs)==Neurovascular unit (NVU)== A layer of brain endothelial cells connected by tight junctions forms the blood-brain barrier. The intimate contact of these specialized endothelial cells with different cell types constitutes the NVU. A basement membrane...