File:Anderson2016-fig12a.jpg: Difference between revisions

Fig. 12a. Mouse E11.5 Developing Heart

The left hand image is from an episcopic dataset prepared from a developing mouse embryo early on E11.5. The section is taken in so-called “four chamber” plane. The atrioventricular canal has expanded rightward so that the right atrium is now in direct continuity (white arrow) with the developing right ventricle (RV). There has also been growth of the primary atrial septum, with the primary foramen now seen between its leading edge, which is capped by mesenchyme, and the cranial margin of the inferior atrioventricular (AV) cushions. Note that there is also a space between the caudal edge of the cushion and the crest of the muscular ventricular septum. This is the reorientated embryonic interventricular foramen.

The right hand panel is a histological section, again taken in the so-called “four chamber plane”, from a human embryo at Carnegie stage 16, representing the end of the fifth week of development. As can be seen, it is directly comparable with the situation as shown in the mouse heart. The section in the human heart is taken between the atrioventricular cushions, which have yet to fuse at this stage of development. This shows that there is a large defect, well described as an atrioventricular septal defect, through which all four cardiac chambers are in free communication.

Figure Links: 1 Heart tube mouse E8 | 2 Ventricular loop mouse E8 | 3 Heart mouse E10.5 | 4 Atrial component mouse E10.5 | 5 Sinus horns mouse E8.5 | 6 Venous valve mouse E10.5 | 7a Left atrium CS14 | 7b Atrioventricular canal CS14 | 8a Atrioventricular canal mouse E10.5 | 8b Outflow tract mouse E10.5 | 9a Atrioventricular canal CS14 | 9b Right ventricle CS14 | 10 Ventricular septal defect | fig 11a | fig 11b | fig 12a | fig 12b | fig 13a | fig 13b | fig 14 | fig 15a | fig 15b | fig 16a | fig 16b | fig 17a | fig 17b | fig 18 | fig 19 | fig 20 | fig 21 | fig 22 | fig 23 | fig 24a | fig 24b | fig 25a | fig 25b |fig 26a | fig 26b | fig 27a | fig 27b | fig 28a | fig 28b | fig 29a | fig 29b | fig 30 | fig 31 | fig 32a | fig 32b | fig 33a | fig 33b | fig 34a | fig 34b | fig 35a | fig 35b | fig 36 | fig 37 | fig 38 | fig 39a | fig 39b | fig 40a | fig 40b | fig 41a | fig 41b | fig 42a | 42b | 43a Stenotic pulmonary valve | 43b Stenotic aortic valve | fig 44a | fig 44b | fig 45a | fig 45b | fig 46a | fig 46b | fig 47 | fig 48 | fig 49 | fig 50a | fig 50b | Figure Gallery

Reference

Anderson RH. Teratogenecity in the setting of cardiac development and maldevelopment. (2016)

Cite this page: Hill, M.A. (2024, April 18) Embryology Anderson2016-fig12a.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Anderson2016-fig12a.jpg

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