File:Adrenal and gonad early development.jpg

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Adrenal and Gonad Early Development

The key events of molecular development of steroidogenic tissues in mice are shown in this cartoon. Dax-1 function in sex determination is still unclear.

  • male sex - SRY, SOX9, NR5A1 (Nuclear Receptor Subfamily 5, Group A, Member 1; SF-1), NR0B1 (Nuclear Receptor Subfamily 0, Group B, Member 1; Dax-1)
  • female sex - WNT4 (Wingless-Type Mmtv Integration Site Family, Member 4), NR0B1 (Nuclear Receptor Subfamily 0, Group B, Member 1; Dax-1), XIST

Links: SOX | WNT | XIST

NR5A1 - Steroidogenic Factor 1

  • NR5A1 - Nuclear Receptor Subfamily 5, Group A, Member 1; Ad4BP (Adrenal 4 Binding Protein) or SF-1 (Steroidogenic Factor 1)
  • 53 kDa protein
  • classical DNA-binding domain (DBD) characterized by two Cys2-Cys2 zinc fingers in the N-terminal region
  • SF-1 binds DNA as a monomer
  • high homology with the drosophila Ftz-F1 transcription factor that controls fushi tarazu homeotic gene expression

OMIM: NR5A1 - Nuclear Receptor Subfamily 5, Group A, Member 1


Val P, Lefrançois-Martinez AM, Veyssière G & Martinez A. (2003). SF-1 a key player in the development and differentiation of steroidogenic tissues. Nucl. Recept. , 1, 8. PMID: 14594453 DOI.


© 2003 Val et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Val et al. Nuclear Receptor 2003 1:8 doi:10.1186/1478-1336-1-8

Original file name: Figure 2. 1478-1336-1-8-2-l.jpg (cartoon cropped from full image)

Cite this page: Hill, M.A. (2024, May 30) Embryology Adrenal and gonad early development.jpg. Retrieved from

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current15:00, 28 May 2011Thumbnail for version as of 15:00, 28 May 2011700 × 397 (50 KB)S8600021 (talk | contribs)==Adrenal and Gonad Early Development== The key events of steroidogenic tissues development in mice are shown. Molecular players in male sex (SRY, SOX9, SF-1, Dax-1) and female sex determination (Wnt4, Dax-1) are shown. Dax-1 function in sex determinatio