Endocrine - Gonad Development
Embryonically, initial endocrine development of the testis is required for development of both the internal genital tract and the external genitalia.
Postnatally, the gonads are part of an integrated Hypothalamus-Pituitary-Gonad (HPG) axis.
- mesoderm - mesothelium and underlying mesenchyme, primordial germ cells
- Gonadal ridge - mesothelium thickening, medial mesonephros
- Primordial Germ cells - yolk sac, to mesentery of hindgut, to genital ridge of developing kidney
- testis-determining factor (TDF) from Y chromosome: presence (testes), absence (ovaries)
- 8 Weeks, mesenchyme, interstitial cells (of Leydig) secrete testosterone, androstenedione
- 8 to 12 Weeks - hCG stimulates testosterone production
- Sustentacular cells - produce anti-mullerian hormone to puberty
- X chromosome genes regulate ovary development
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Cite this page: Hill, M.A. (2019, September 19) Embryology Endocrine - Gonad Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Endocrine_-_Gonad_Development
- © Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G