Endocrine - Gonad Development
|Embryology - 19 Sep 2019 Expand to Translate|
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Embryonically, initial endocrine development of the testis is required for development of both the internal genital tract and the external genitalia.
Postnatally, the gonads are part of an integrated Hypothalamus-Pituitary-Gonad (HPG) axis.
|Endocrine Links: Introduction | BGD Lecture | Science Lecture | Lecture Movie | pineal | hypothalamus | pituitary | thyroid | parathyroid | thymus | pancreas | adrenal | endocrine gonad | endocrine placenta | other tissues | Stage 22 | endocrine abnormalities | Hormones | Category:Endocrine|
Some Recent Findings
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
Search term: Endocrine Gonad Development
<pubmed limit=5>Endocrine Gonad Development</pubmed>
- mesoderm - mesothelium and underlying mesenchyme, primordial germ cells
- Gonadal ridge - mesothelium thickening, medial mesonephros
- Primordial Germ cells - yolk sac, to mesentery of hindgut, to genital ridge of developing kidney
- testis-determining factor (TDF) from Y chromosome: presence (testes), absence (ovaries)
- 8 Weeks, mesenchyme, interstitial cells (of Leydig) secrete testosterone, androstenedione
- 8 to 12 Weeks - hCG stimulates testosterone production
- Sustentacular cells - produce anti-mullerian hormone to puberty
- X chromosome genes regulate ovary development
Male Hormone Levels
Human Male Testosterone and Anti-Müllerian Hormone (AMH) relative levels
Leydig cells stained for LHCGR1
Androgen and Digit ratio (2D:4D)
The ratio of 2nd and 4th finger (D, digit) length. This ratio has been suggested to relate to high fetal testosterone concentration (males have lower 2D:4D than females) and has been shown for several species. Although a study in mice has not shown the same correlation. There have been some suggestions that the ratio may also be an indicator of various neurological abnormalities.
To measure (2D:4D) - using your right hand palm up, measure the index finger (2) and ring finger (4) length from palm to tip. Dividing the index finger by the ring finger gives the 2D:4D ratio, average women ratio is 1, average men is 0.98.
|Genital Links: genital | Lecture - Medicine | Lecture - Science | Lecture Movie | Medicine - Practical | primordial germ cell | meiosis | Female | X | ovary | corpus luteum | oocyte | uterus | vagina | reproductive cycles | menstrual cycle | Male | Y | SRY | testis | spermatozoa | ductus deferens | penis | prostate | endocrine gonad | Genital Movies | genital abnormalities | Assisted Reproductive Technology | puberty | Category:Genital|
- <pubmed>16544032</pubmed>| Arq Bras Endocrinol Metabol.
Search Pubmed: endocrine gonad development
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- Andrology Australia - Androgen deficiency PDF | Childhood and adolescence. Examination of male genitals and secondary sexual characteristics PDF
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Cite this page: Hill, M.A. (2019, September 19) Embryology Endocrine - Gonad Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Endocrine_-_Gonad_Development
- © Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G