Endocrine - Gonad Development

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Gonad

Female HPG axis

Lecture - Genital Development | UNSW Embryology - Gonads see also previous Sexual Differentiation Lecture/Practical

HPG Axis - Endocrinology - Simplified diagram of the actions of gonadotrophins

Gonad Development

  • mesoderm - mesothelium and underlying mesenchyme, primordial germ cells
  • Gonadal ridge - mesothelium thickening, medial mesonephros
  • Primordial Germ cells - yolk sac, to mesentery of hindgut, to genital ridge of developing kidney

Differentiation

  • testis-determining factor (TDF) from Y chromosome: presence (testes), absence (ovaries)

Testis

  • 8 Weeks, mesenchyme, interstitial cells (of Leydig) secrete testosterone, androstenedione
  • 8 to 12 Weeks - hCG stimulates testosterone production
  • Sustentacular cells - produce anti-mullerian hormone to puberty

Ovary

  • X chromosome genes regulate ovary development
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