Embryology History - Shinya Yamanaka
From Embryology
Introduction
Draft Page
- Links: Induced Stem Cells | Stem Cells
Some Recent Findings
The Nobel Prize in Physiology or Medicine 2012 was awarded jointly to Sir John B. Gurdon and Shinya Yamanaka
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Recent References | References
Yamanaka Factors
Yamanaka Factors[1][2] Are a set of 4 transcription factors when introduced into cells induces stem cell formation. These four transcription factors can be expressed from doxycycline (dox)-inducible lentiviral vectors.
OCT4
- Transcription factors containing the POU homeodomain
- Links: OMIM - OCT4
SOX2
- Sry-related HMG-Box gene 2
- Links: OMIM - SOX2
KLF4
- Kruppel-like factor 4, zinc finger protein, transcription factor which acts as both an activator and repressor.
- Links: OMIM - KLF4
cMyc
- The MYC protooncogene encodes a DNA-binding factor that can activate and repress transcription.
- Ectopic expression of c-Myc can also cause tumorigenicity in offspring.
- Links: OMIM - MYC
- More recently shown that Oct4 together with either Klf4 or c-Myc is sufficient to generate iPS cells from neural stem cells.[3]
- Tbx3 transcription factor significantly improves the quality of iPS cells.[4]
References
Reviews
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Articles
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Journal of Visualized Experiments - Generating iPS Cells from MEFS through Forced Expression of Sox-2, Oct-4, c-Myc, and Klf4
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