Embryology History - Nicole Le Douarin: Difference between revisions

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Introduction

Nicole Le Douarin

Nicole Le Douarin has a long research career, her research area has been mainly on the development of neural crest cells using originally a Chicken-Quail chimera model she had developed.

Recently, a paper has been dedicated to her original PhD work on the development of the gastrointestinal tract.^[1]Antero-posterior patterning of the vertebrate digestive tract: 40 years after Nicole Le Douarin's PhD thesis. Int J Dev Biol. 2005;49(2-3):335-47. "This review is dedicated to the work on chick digestive tract organogenesis that Nicole Le Douarin performed as a PhD student under the direction of Etienne Wolf.", see also. ^[2]

Links: Neural Crest Development | Chicken Development

Related Histology Researchers
Santiago Ramón y Cajal \| Camillo Golgi

Developmental hematopoiesis: historical background and perspectives. An interview with Nicole le Douarin. Interview by Charles Durand and Thierry Jaffredo.^[3]

"Nicole le Douarin has shown a long lasting interest for developmental hematopoiesis. Starting from her early research experience, we travel along the main discoveries and concepts that have shaped the modern view of developmental hematopoiesis. All through, we survey the seminal contribution of the "Ecole de Nogent" about lymphocyte homing and the discovery of endothelial-specific tyrosine kinases. This interview is a promenade through the past and present of developmental hematopoiesis narrated by an exceptional personality and an outstanding scientist."

Some Recent Findings

Review - The neural crest, a multifaceted structure of the vertebrates^[4] "In this review, several features of the cells originating from the lateral borders of the primitive neural anlagen, the neural crest (NC) are considered. Among them, their multipotentiality, which together with their migratory properties, leads them to colonize the developing body and to participate in the development of many tissues and organs. The in vitro analysis of the developmental capacities of single NC cells (NCC) showed that they present several analogies with the hematopoietic cells whose differentiation involves the activity of stem cells endowed with different arrays of developmental potentialities. The permanence of such NC stem cells in the adult organism raises the problem of their role at that stage of life. The NC has appeared during evolution in the vertebrate phylum and is absent in their Protocordates ancestors. The major role of the NCC in the development of the vertebrate head points to a critical role for this structure in the remarkable diversification and radiation of this group of animals."
Sonic Hedgehog promotes the survival of neural crest cells by limiting apoptosis induced by the dependence receptor CDON during branchial arch development^[5] "Cell-adhesion molecule-related/Downregulated by Oncogenes (CDO or CDON) was identified as a receptor for the classic morphogen Sonic Hedgehog (SHH). It has been shown that, in cell culture, CDO also behaves as a SHH dependence receptor: CDO actively triggers apoptosis in absence of SHH via a proteolytic cleavage in CDO intracellular domain. We present evidence that CDO is also pro-apoptotic in the developing neural tube where SHH is known to act as a survival factor. SHH, produced by the ventral foregut endoderm, was shown to promote survival of facial neural crest cells (NCCs) that colonize the first branchial arch (BA1). We show here that the survival activity of SHH on neural crest cells is due to SHH-mediated inhibition of CDO pro-apoptotic activity. Silencing of CDO rescued NCCs from apoptosis observed upon SHH inhibition in the ventral foregut endoderm. Thus, the pair SHH/dependence receptor CDO may play an important role in neural crest cell survival during the formation of the first branchial arch."

References

↑ <pubmed>15906249</pubmed>| Int J Dev Biol. Abstract
↑ <pubmed>9376321</pubmed>
↑ <pubmed>20711976</pubmed>| Int J Dev Biol.
↑ <pubmed>25219958</pubmed>
↑ <pubmed>25193697</pubmed>

Reviews

Dupin E, Creuzet S, Le Douarin NM. The Contribution of the Neural Crest to the Vertebrate Body. In: Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-. Available from: http://www.ncbi.nlm.nih.gov/books/NBK6098/

Search PubMed

Search April 2006 "Le Douarin N" 322 reference articles of which 42 were reviews.

Search PubMed: term = Le Douarin N

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation. Collège de France Chaire d'Embryologie cellulaire et moléculaire

Glossary Links

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Cite this page: Hill, M.A. (2024, April 19) Embryology Embryology History - Nicole Le Douarin. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Embryology_History_-_Nicole_Le_Douarin

What Links Here?

[1] <pubmed>15906249</pubmed>| Int J Dev Biol. Abstract

[2] <pubmed>9376321</pubmed>

[PMID20711976-3] <pubmed>20711976</pubmed>| Int J Dev Biol.

[PMID25219958-4] <pubmed>25219958</pubmed>

[PMID25193697-5] <pubmed>25193697</pubmed>

[1]

[2]

[3]

[4]

[5]

@@ Line 12: / Line 12: @@
 {{History People}}
-'''Developmental hematopoiesis: historical background and perspectives. An interview with Nicole le Douarin.''' Interview by Charles Durand and Thierry Jaffredo.<ref name = "PMID20711976><pubmed>20711976</pubmed>| [http://www.ijdb.ehu.es/web/paper.php?doi=10.1387/ijdb.103154cd Int J Dev Biol.]</ref>
+'''Developmental hematopoiesis: historical background and perspectives. An interview with Nicole le Douarin.''' Interview by Charles Durand and Thierry Jaffredo.<ref name="PMID20711976"><pubmed>20711976</pubmed>| [http://www.ijdb.ehu.es/web/paper.php?doi=10.1387/ijdb.103154cd Int J Dev Biol.]</ref>
 :"Nicole le Douarin has shown a long lasting interest for developmental hematopoiesis. Starting from her early research experience, we travel along the main discoveries and concepts that have shaped the modern view of developmental hematopoiesis. All through, we survey the seminal contribution of the "Ecole de Nogent" about lymphocyte homing and the discovery of endothelial-specific tyrosine kinases. This interview is a promenade through the past and present of developmental hematopoiesis narrated by an exceptional personality and an outstanding scientist."
+== Some Recent Findings ==
+{|
+|-bgcolor="F5FAFF"
+|
+* '''Review - The neural crest, a multifaceted structure of the vertebrates'''<ref name="PMID25219958"><pubmed>25219958</pubmed></ref> "In this review, several features of the cells originating from the lateral borders of the primitive neural anlagen, the neural crest (NC) are considered. Among them, their multipotentiality, which together with their migratory properties, leads them to colonize the developing body and to participate in the development of many tissues and organs. The in vitro analysis of the developmental capacities of single NC cells (NCC) showed that they present several analogies with the hematopoietic cells whose differentiation involves the activity of stem cells endowed with different arrays of developmental potentialities. The permanence of such NC stem cells in the adult organism raises the problem of their role at that stage of life. The NC has appeared during evolution in the vertebrate phylum and is absent in their Protocordates ancestors. The major role of the NCC in the development of the vertebrate head points to a critical role for this structure in the remarkable diversification and radiation of this group of animals."
+* '''Sonic Hedgehog promotes the survival of neural crest cells by limiting apoptosis induced by the dependence receptor CDON during branchial arch development'''<ref name="PMID25193697"><pubmed>25193697</pubmed></ref> "Cell-adhesion molecule-related/Downregulated by Oncogenes (CDO or CDON) was identified as a receptor for the classic morphogen Sonic Hedgehog (SHH). It has been shown that, in cell culture, CDO also behaves as a SHH dependence receptor: CDO actively triggers apoptosis in absence of SHH via a proteolytic cleavage in CDO intracellular domain. We present evidence that CDO is also pro-apoptotic in the developing neural tube where SHH is known to act as a survival factor. SHH, produced by the ventral foregut endoderm, was shown to promote survival of facial neural crest cells (NCCs) that colonize the first branchial arch (BA1). We show here that the survival activity of SHH on neural crest cells is due to SHH-mediated inhibition of CDO pro-apoptotic activity. Silencing of CDO rescued NCCs from apoptosis observed upon SHH inhibition in the ventral foregut endoderm. Thus, the pair SHH/dependence receptor CDO may play an important role in neural crest cell survival during the formation of the first branchial arch."
+|}
 ==References==
 <references/>
 === Reviews ===
 <pubmed>16313387</pubmed>