Embryology History - John Saunders: Difference between revisions
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==Introduction== | ==Introduction== | ||
John Saunders Jr has had his research reviewed twice in recent years, in 2002 | John Saunders Jr has had his research reviewed twice in recent years, in 2002<ref name="PMID12455620 "><pubmed>12455620 </pubmed></ref> and again in 2017.<ref name="PMID28625869"><pubmed>28625869</pubmed></ref> | ||
This text from | |||
This text abstract from the recent review of John Saunders research.<ref name="PMID28625869"><pubmed>28625869</pubmed></ref> | |||
:"John Saunders was a highly skilled embryologist who pioneered the study of limb development. His studies on chick embryos provided the fundamental framework for understanding how vertebrate limbs develop. This framework inspired generations of scientists and formed the bridge from experimental embryology to molecular mechanisms. Saunders investigated how feathers become organized into tracts in the skin of the chick wing and also identified regions of programmed cell death. He discovered that a region of thickened ectoderm that rims the chick wing bud - the apical ectodermal ridge - is required for outgrowth and the laying down of structures along the proximo-distal axis (long axis) of the wing, identified the zone of polarizing activity (ZPA; polarizing region) that controls development across the anteroposterior axis ("thumb to little finger "axis) and contributed to uncovering the importance of the ectoderm in development of structures along the dorso-ventral axis ( "back of hand to palm" axis). This review looks in depth at some of his original papers and traces how he made the crucial findings about how limbs develop, considering these findings both in the context of contemporary knowledge at the time and also in terms of their immediate impact on the field." | :"John Saunders was a highly skilled embryologist who pioneered the study of limb development. His studies on chick embryos provided the fundamental framework for understanding how vertebrate limbs develop. This framework inspired generations of scientists and formed the bridge from experimental embryology to molecular mechanisms. Saunders investigated how feathers become organized into tracts in the skin of the chick wing and also identified regions of programmed cell death. He discovered that a region of thickened ectoderm that rims the chick wing bud - the apical ectodermal ridge - is required for outgrowth and the laying down of structures along the proximo-distal axis (long axis) of the wing, identified the zone of polarizing activity (ZPA; polarizing region) that controls development across the anteroposterior axis ("thumb to little finger "axis) and contributed to uncovering the importance of the ectoderm in development of structures along the dorso-ventral axis ( "back of hand to palm" axis). This review looks in depth at some of his original papers and traces how he made the crucial findings about how limbs develop, considering these findings both in the context of contemporary knowledge at the time and also in terms of their immediate impact on the field." | ||
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Introduction
John Saunders Jr has had his research reviewed twice in recent years, in 2002[1] and again in 2017.[2]
This text abstract from the recent review of John Saunders research.[2]
- "John Saunders was a highly skilled embryologist who pioneered the study of limb development. His studies on chick embryos provided the fundamental framework for understanding how vertebrate limbs develop. This framework inspired generations of scientists and formed the bridge from experimental embryology to molecular mechanisms. Saunders investigated how feathers become organized into tracts in the skin of the chick wing and also identified regions of programmed cell death. He discovered that a region of thickened ectoderm that rims the chick wing bud - the apical ectodermal ridge - is required for outgrowth and the laying down of structures along the proximo-distal axis (long axis) of the wing, identified the zone of polarizing activity (ZPA; polarizing region) that controls development across the anteroposterior axis ("thumb to little finger "axis) and contributed to uncovering the importance of the ectoderm in development of structures along the dorso-ventral axis ( "back of hand to palm" axis). This review looks in depth at some of his original papers and traces how he made the crucial findings about how limbs develop, considering these findings both in the context of contemporary knowledge at the time and also in terms of their immediate impact on the field."
| Embryologists: William Hunter | Wilhelm Roux | Caspar Wolff | Wilhelm His | Oscar Hertwig | Julius Kollmann | Hans Spemann | Francis Balfour | Charles Minot | Ambrosius Hubrecht | Charles Bardeen | Franz Keibel | Franklin Mall | Florence Sabin | George Streeter | George Corner | James Hill | Jan Florian | Thomas Bryce | Thomas Morgan | Ernest Frazer | Francisco Orts-Llorca | José Doménech Mateu | Frederic Lewis | Arthur Meyer | Robert Meyer | Erich Blechschmidt | Klaus Hinrichsen | Hideo Nishimura | Arthur Hertig | John Rock | Viktor Hamburger | Mary Lyon | Nicole Le Douarin | Robert Winston | Fabiola Müller | Ronan O'Rahilly | Robert Edwards | John Gurdon | Shinya Yamanaka | Embryology History | Category:People | ||
|
References
<pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed> <pubmed>9846378</pubmed>
1: Saunders JW Jr. The proximo-distal sequence of origin of the parts of the
chick wing and the role of the ectoderm. 1948. J Exp Zool. 1998 Dec
15;282(6):628-68. PubMed PMID: 9846378.
2: Saunders JW Jr. Trink, the man. Dev Dyn. 2003 Dec;228(4):588-90. PubMed PMID:
14648834.
3: Saunders JW Jr. How serendipity shaped a life; an interview with John W.
Saunders, Jr. by John F. Fallon. Int J Dev Biol. 2002;46(7):853-61. PubMed PMID:
12455620.
4: Saunders JW Jr. Is the progress zone model a victim of progress? Cell. 2002
Sep 6;110(5):541-3. Review. PubMed PMID: 12230971.
5: Saunders JW Jr. Apical ectodermal ridge in retrospect. J Exp Zool. 1998 Dec
15;282(6):669-76. PubMed PMID: 9846379.
6: Saunders JW Jr. Operations on limb buds of avian embryos. Methods Cell Biol.
1996;51:125-45. Review. PubMed PMID: 8722474.
7: Feinberg RN, Repo MA, Saunders JW Jr. Ectodermal control of the avascular zone
of the peripheral mesoderm in the chick embryo. J Exp Zool. 1983
Jun;226(3):391-8. PubMed PMID: 6193241.
8: Feinberg RN, Saunders JW Jr. Effects of excising the apical ectodermal ridge
on the development of the marginal vasculature of the wing bud in the chick
embryo. J Exp Zool. 1982 Feb 20;219(3):345-54. PubMed PMID: 7061977.
9: Errick JE, Saunders JW Jr. Limb outgrowth in the chick embryo induced by
dissociated and reaggregated cells of the apical ectodermal ridge. Dev Biol. 1976
May;50(1):26-34. PubMed PMID: 1269832.
10: Saunders JW Jr, Gasseling MT, Errick JE. Inductive activity and enduring
cellular constitution of a supernumerary apical ectodermal ridge grafted to the
limb bud of the chick embryo. Dev Biol. 1976 May;50(1):16-25. PubMed PMID:
1269827.
11: Errick JE, Saunders JW Jr. Effects of an "inside-out" limb-bud ectoderm on
development of the avian limb. Dev Biol. 1974 Dec;41(2):338-51. PubMed PMID:
4452413.
12: MacCabe JA, Errick J, Saunders JW Jr. Ectodermal control of the dorsoventral
axis in the leg bud of the chick embryo. Dev Biol. 1974 Jul;39(1):69-82. PubMed
PMID: 4836526.
13: Saunders JW Jr, Reuss C. Inductive and axial properties of prospective
wing-bud mesoderm in the chick embryo. Dev Biol. 1974 May;38(1):41-50. PubMed
PMID: 4826292.
14: MacCabe JA, Saunders JW Jr, Pickett M. The control of the anteroposterior and
dorsoventral axes in embryonic chick limbs constructed of dissociated and
reaggregated limb-bud mesoderm. Dev Biol. 1973 Apr;31(2):323-35. PubMed PMID:
4787203.
15: Maccabe AB, Gasseling MT, Saunders JW Jr. Spatiotemporal distribution of
mechanisms that control outgrowth and anteroposterior polarization of the limb
bud in the chick embryo. Mech Ageing Dev. 1973 Apr-May;2(1):1-12. PubMed PMID:
4719010.
16: Saunders JW Jr. Developmental control of three-dimensional polarity in the
avian limb. Ann N Y Acad Sci. 1972 Aug 25;193:29-42. Review. PubMed PMID:
4561097.
17: Rubin L, Saunders JW Jr. Ectodermal-mesodermal interactions in the growth of
limb buds in the chick embryo: constancy and temporal limits of the ectodermal
induction. Dev Biol. 1972 May;28(1):94-112. PubMed PMID: 4625230.
18: Saunders JW Jr. Edgar Zwilling; an appreciation. Dev Biol. 1971
Sep;26(1):165-9. PubMed PMID: 4939251.
19: Tupper J, Saunders JW Jr, Edwards C. The onset of electrical communication
between cells in the developing starfish embryo. J Cell Biol. 1970
Jul;46(1):187-91. PubMed PMID: 5459008; PubMed Central PMCID: PMC2108076.
20: Fallon JF, Saunders JW Jr. In vitro analysis of the control of cell death in
a zone of prospective necrosis from the chick wing bud. Dev Biol. 1968
Dec;18(6):553-70. PubMed PMID: 5710080.
21: Saunders JW Jr. Death in embryonic systems. Science. 1966 Nov
4;154(3749):604-12. Review. PubMed PMID: 5332319.
22: McWhinnie DJ, Saunders JW Jr. Developmental patterns and specificities of
alkaline phosphatase in the embryonic chick limb. Dev Biol. 1966
Oct;14(2):169-91. PubMed PMID: 4382022.
23: SAUNDERS JW Jr, GASSELING MT. Trans-filter propagation of apical ectoderm
maintenance factor in the chick embrvo wing bud. Dev Biol. 1963 Mar;6:64-78.
PubMed PMID: 13986823.
24: SAUNDERS JW Jr, GASSELING MT. Cellular death in morphogenesis of the avian
wing. Dev Biol. 1962 Aug;5:147-78. PubMed PMID: 14497532.
25: BELL E, GASSELING MT, SAUNDERS JW Jr, ZWILLING E. On the role of ectoderm in
limb development. Dev Biol. 1962 Feb;4:177-96. PubMed PMID: 13866799.
26: ABRAMOFF P, SAUNDERS JW Jr, GASSELING MT. Cytotoxicity of heterologous immune
chicken serum to normal and neoplastic mouse tissues in culture. J Natl Cancer
Inst. 1961 Mar;26:585-99. PubMed PMID: 13681112.
27: GASSELING MT, SAUNDERS JW Jr. Effects of the apical ectodermal ridge on
growth of the versene-stripped chick limb bud. Dev Biol. 1961 Feb;3:1-25. PubMed
PMID: 13703849.
28: BELL E, SAUNDERS JW Jr, ZWILLING E. Limb development in the absence of
ectodermal ridge. Nature. 1959 Nov 28;184(Suppl 22):1736-7. PubMed PMID:
13798486.
29: SAUNDERS JW Jr, GASSELING MT. Effects of reorienting the wing-bud apex in the
chick embryo. J Exp Zool. 1959 Oct-Dec;142:553-69. PubMed PMID: 13746798.
30: ABRAMOFF P, CHINCHINIAN H, SAUNDERS JW Jr. Detection of antigenically
distinctive components of mouse melanoma S91. J Natl Cancer Inst. 1959
May;22(5):919-25. PubMed PMID: 13655070.
31: SAUNDERS JW Jr, GASSELING MT, GFELLER M. Interactions of ectoderm and
mesoderm in the origin of axial relationships in the wing of the fowl. J Exp
Zool. 1958 Feb;137(1):39-74. PubMed PMID: 13563785.
32: SAUNDERS JW Jr, QUEVEDO WC, PIERRO L, MORBECK FE. The effects of tyrosine and
phenylalanine on the synthesis of pigment in melanocytes of embryonic chick skin
cultured in vitro. J Natl Cancer Inst. 1955 Oct;16(2):475-87. PubMed PMID:
13263916.
33: SAUNDERS JW Jr, GASSELING MT, CAIRNS JM. Effect of implantation site on the
development of an implant in the chick embryo. Nature. 1955 Apr
16;175(4459):673-4. PubMed PMID: 14370190.
34: O'BRIEN JP, BELLI JA, WOOD DE, SAUNDERS JW Jr. A new technique for the study
of the effects of x-radiation on mammalian skin maintained at different
temperatures during exposure. Science. 1953 Jul 31;118(3057):135-6. PubMed PMID:
13076213.
35: SAUNDERS JW Jr. The proximo-distal sequence of origin of the parts of the
chick wing and the role of the ectoderm. J Exp Zool. 1948 Aug;108(3):363-403.
PubMed PMID: 18882505.
36: SAUNDERS JW Jr. An experimental study of the distribution, orientation, and
tract specificity of feather germs in the wing of the chick embryo. Anat Rec.
1947 Dec;99(4):647. PubMed PMID: 18935452.
37: SAUNDERS JW Jr. The proximo-distal sequence of origin of wing parts and the
role of the ectoderm. Anat Rec. 1947 Dec;99(4):567. PubMed PMID: 18895365.
Search PubMed
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Cite this page: Hill, M.A. (2024, April 24) Embryology Embryology History - John Saunders. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Embryology_History_-_John_Saunders
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
