Embryology History - John Gurdon: Difference between revisions

From Embryology
Line 38: Line 38:
<references/>
<references/>
===Reviews===
===Reviews===
<pubmed>16134025</pubmed>
<pubmed></pubmed>
<pubmed></pubmed>
<pubmed></pubmed>
<pubmed></pubmed>
<pubmed></pubmed>


===Articles===
===Articles===

Revision as of 17:54, 9 October 2012

Introduction

John Gurdon used nuclear transplantation and cloning to show that the nucleus of a differentiated somatic cell retains the totipotency necessary to form a whole organism.

2003 Current Biology Interview PMID 14521852 2009 Interview - "The birth of cloning" PMID 19132124

Links: Frog Development | | Stem Cells

Some Recent Findings

Xenopus androgenetic haploids, hybrids and cybrids[1]

The Nobel Prize in Physiology or Medicine 2012 was awarded jointly to Sir John B. Gurdon and Shinya Yamanaka

"for the discovery that mature cells can be reprogrammed to become pluripotent"
  • Deficient induction response in a Xenopus nucleocytoplasmic hybrid[1] "Incompatibilities between the nucleus and the cytoplasm of sufficiently distant species result in developmental arrest of hybrid and nucleocytoplasmic hybrid (cybrid) embryos. Several hypotheses have been proposed to explain their lethality, including problems in embryonic genome activation (EGA) and/or nucleo-mitochondrial interactions. ... Altogether, our study demonstrates that the egg cytoplasm of one species may not support the development promoted by the nucleus of another species, even if this nucleus does not interfere with the cytoplasmic/maternal functions of the egg, while the egg cytoplasm is also capable of activating the genome of that nucleus. Instead, our results provide evidence that inefficient signalling and differences in the concentrations of key proteins between species lead to developmental defects in cybrids. Finally, they show that the incompatibilities of cybrids can be corrected by appropriate treatments."


Recent References | References

Research History

Key Papers

Historic Embryologists

Embryologists: William Hunter | Wilhelm Roux | Caspar Wolff | Wilhelm His | Oscar Hertwig | Julius Kollmann | Hans Spemann | Francis Balfour | Charles Minot | Ambrosius Hubrecht | Charles Bardeen | Franz Keibel | Franklin Mall | Florence Sabin | George Streeter | George Corner | James Hill | Jan Florian | Thomas Bryce | Thomas Morgan | Ernest Frazer | Francisco Orts-Llorca | José Doménech Mateu | Frederic Lewis | Arthur Meyer | Robert Meyer | Erich Blechschmidt | Klaus Hinrichsen | Hideo Nishimura | Arthur Hertig | John Rock | Viktor Hamburger | Mary Lyon | Nicole Le Douarin | Robert Winston | Fabiola Müller | Ronan O'Rahilly | Robert Edwards | John Gurdon | Shinya Yamanaka | Embryology History | Category:People
Related Histology Researchers  
Santiago Ramón y Cajal | Camillo Golgi

References

  1. 1.0 1.1 <pubmed>22131902</pubmed>| PLoS Biol. Cite error: Invalid <ref> tag; name 'PMID22131902' defined multiple times with different content

Reviews

<pubmed>16134025</pubmed> <pubmed></pubmed> <pubmed></pubmed>

Articles

<pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed>

<pubmed>5530658</pubmed> <pubmed>5531072</pubmed> <pubmed>5967799</pubmed> <pubmed>13903027</pubmed> <pubmed>13726553</pubmed>

Search PubMed

Search PubMed Now: Gurdon+J

Terms

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.



Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Cite this page: Hill, M.A. (2024, March 28) Embryology Embryology History - John Gurdon. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Embryology_History_-_John_Gurdon

What Links Here?
© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G