Ductus Deferens Development: Difference between revisions

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Embryology - 16 Apr 2024 Expand to Translate
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Introduction

Historic testis drawing

The male internal genital tract leaving each of the male testis is the ductus deferens (vas deferens; Latin "carrying-away vessel"; plural: vasa deferentia).

Historic Embryology - Genital
General: 1901 Urinogenital Tract \| 1902 The Uro-Genital System \| 1904 Ovary and Testis \| 1912 Urinogenital Organ Development \| 1914 External Genitalia \| 1921 Urogenital Development \| 1921 External Genital \| 1942 Sex Cords \| 1953 Germ Cells \| Historic Embryology Papers \| Historic Disclaimer
Female: 1904 Ovary and Testis \| 1904 Hymen \| 1912 Urinogenital Organ Development \| 1914 External Genitalia \| 1914 Female \| 1921 External Genital \| 1927 Female Foetus 15 cm \| 1927 Vagina \| 1932 Postnatal Ovary
Male: 1887-88 Testis \| 1904 Ovary and Testis \| 1904 Leydig Cells \| 1906 Testis vascular \| 1909 Prostate \| 1912 Prostate \| 1914 External Genitalia \| 1915 Cowper’s and Bartholin’s Glands \| 1920 Wolffian tubules \| 1935 Prepuce \| 1935 Wolffian Duct \| 1942 Sex Cords \| 1943 Testes Descent \| Historic Embryology Papers \| Historic Disclaimer

Some Recent Findings

More recent papers
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link. This search now requires a manual link as the original PubMed extension has been disabled. The displayed list of references do not reflect any editorial selection of material based on content or relevance. References also appear on this list based upon the date of the actual page viewing. References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability. More? References \| Discussion Page \| Journal Searches \| 2019 References \| 2020 References Search term: Ductus Deferens Embryology \| Ductus Deferens Development \| Vas Deferens Development

Older papers
These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table. See also the Discussion Page for other references listed by year and References on this current page.

Abnormalities

Male Infertility Genes

**Selected genes in Male Infertility**
Gene abbreviation	Name	Gene Location	Online Mendelian Inheritance in Man (OMIM)	HUGO Gene Nomenclature Committee (HGNC)	GeneCards (GCID)	Diagnosis
AURKC	Aurora kinase C	19q13.43	603495	11391	GC19P057230	Macrozoospermia
CATSPER1	Cation channel sperm-associated 1	11q13.1	606389	17116	GC11M066034	Asthenozoospermia
CFTR	Cystic fibrosis transmembrane conductance regulator	7q31.2	602421	1884	GC07P117465	Obstructive azoospermia
DNAH1	Dynein axonemal heavy chain 1	3p21.1	603332	2940	GC03P052350	Asthenozoospermia
DPY19L2	Dpy-19-like 2 gene	12q14.2	613893	19414	GC12M063558	Globozoospermia
GALNTL5	Polypeptide N-acetylgalactosaminyltransferase-like 5	7q36.1	615133	21725	GC07P151956	Asthenozoospermia
MAGEB4	MAGE family member B4	Xp21.2	300153	6811	GC0XP030260	Azoospermia
NANOS1	Nanos C2HC-type zinc finger 1	10q26.11	608226	23044	GC10P119029	Azoospermia
NR0B1	Nuclear receptor subfamily 0 group B member 1	Xp21.2	300473	7960	GC0XM030322	Azoospermia
NR5A1	Nuclear receptor subfamily 5 group A member 1	9q33.3	184757	7983	GC09M124481	Azoospermia
SOHLH1	Spermatogenesis and oogenesis-specific basic helix–loop–helix 1	9q34.3	610224	27845	C09M135693	Azoospermia
vSPATA16	Spermatogenesis-associated 16	3q26.31	609856	29935	GC03M172889	Globozoospermia
SYCE1	Synaptonemal complex central element protein 1	10q26.3	611486	28852	GC10M133553	Azoospermia
TAF4B	TATA-box binding protein-associated factor 4b	18q11.2	601689	11538	GC18P026225	Azoospermia
TEX11	Testis expressed 11	Xq13.1	300311	11733	GC0XM070528	Azoospermia
TEX15	Testis expressed 15, meiosis and synapsis associated	8p12	605795	11738	GC08M030808	Azoospermia
WT1	Wilms tumour 1	8p12	607102	12796	GC11M032365	Azoospermia
ZMYND15	Zinc-finger MYND-type containing 15	17p13.2	614312	20997	GC17P004740	Azoospermia
Table data source^[1] (table 1) Links: fertilization \| spermatozoa \| testis \| Male Infertility Genes \| Female Infertility Genes \| oocyte \| ovary \| Genetic Abnormalities \| ART Asthenozoospermia - (asthenospermia) term for reduced spermatozoa motility. Azoospermia - term for no spermatozoa located in the ejaculate. Globozoospermia - term for spermatozoa with a round head and no acrosome.

International Classification of Diseases

ICD-11 5A81 Testicular dysfunction or testosterone-related disorders

LB51 Anorchia or microorchidia - A disorder affecting males, caused by an abnormality occurring in sex development during the antenatal period. This disorder is characterized by individuals who are born with absence of the testes, or with testes that are deficient in size and function. Confirmation is by physical examination, identification of low testosterone levels but elevated follicle stimulating hormone and luteinizing hormone levels in a blood sample, or imaging.

LB58 Polyorchidism - A condition of the testes, caused by determinants arising during the antenatal period. This condition is characterized by the presence of more than two testicles. Confirmation is by imaging.

5A81.0 Testicular hyperfunction - A hypersecretion of testicular hormones.

5A81.1 Testicular hypofunction - In pre-puberty, a disorder characterized by atrophied testes and sterility, abnormal height and absence of secondary sex characteristics. In post-puberty, a disorder characterized by depressed sexual function, loss of sex drive and sterility, muscle weakness and osteoporosis (due to loss of the androgen anabolic effect).

GB04.0 Azoospermia - Any condition of the genital system affecting males, caused by obstruction of the reproductive tract, abnormal hormone levels, testicular failure, or inadequate production of spermatozoa. These conditions are characterized by the absence of a measurable level of sperm cells in semen, and very low levels of fertility. Confirmation is by the absence of spermatozoa in the sediment of a centrifuged sample of ejaculate.

GB03 Atrophy of testis - A condition of the testis, caused by apoptosis of the cells due to diminished cellular proliferation, decreased cellular volume, decreased function, ischemia, malnutrition, disease, infection, mutation, or hormonal changes. This condition is characterized by a partial or complete decrease in size and function of the testis tissue.

GB00 Hydrocele or spermatocele - A condition characterized by an accumulation of serous fluid in the tunica vaginalis testis or along the spermatic cord, and cystic swelling containing fluid and dead spermatozoa of the testicular epididymis, rete testis or efferent ductuli.

LB52 Cryptorchidism - A disorder affecting males, caused by an abnormality occurring in sex development during the antenatal period. This disorder is characterized by the absence of one or both testes from the scrotum. This disorder may also present with reduced fertility, psychological implications, or increased risk of testicular germ cell tumours. Confirmation is by imaging, karyotyping, or identification of male sex hormones in a blood sample.

genital abnormalities | ICD-11

References

↑ Harper JC, Aittomäki K, Borry P, Cornel MC, de Wert G, Dondorp W, Geraedts J, Gianaroli L, Ketterson K, Liebaers I, Lundin K, Mertes H, Morris M, Pennings G, Sermon K, Spits C, Soini S, van Montfoort APA, Veiga A, Vermeesch JR, Viville S & Macek M. (2018). Recent developments in genetics and medically assisted reproduction: from research to clinical applications. Eur. J. Hum. Genet. , 26, 12-33. PMID: 29199274 DOI.

Reviews

de Mello Santos T & Hinton BT. (2019). We, the developing rete testis, efferent ducts, and Wolffian duct, all hereby agree that we need to connect. Andrology , , . PMID: 31033257 DOI.

External Links

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Glossary Links

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Cite this page: Hill, M.A. (2024, April 16) Embryology Ductus Deferens Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Ductus_Deferens_Development

What Links Here?

[PMID29199274-1] Harper JC, Aittomäki K, Borry P, Cornel MC, de Wert G, Dondorp W, Geraedts J, Gianaroli L, Ketterson K, Liebaers I, Lundin K, Mertes H, Morris M, Pennings G, Sermon K, Spits C, Soini S, van Montfoort APA, Veiga A, Vermeesch JR, Viville S & Macek M. (2018). Recent developments in genetics and medically assisted reproduction: from research to clinical applications. Eur. J. Hum. Genet. , 26, 12-33. PMID: 29199274 DOI.

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