Developmental Signals - Tbx
Embryology - 28 Mar 2024 Expand to Translate |
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Introduction
Genes in the TBX gene family provide instructions for making proteins called T-box proteins that play critical roles during embryonic development. These proteins are especially important for normal development of the arms, hands, and heart. T-box proteins regulate the activity of other genes by attaching (binding) to specific regions of DNA. On the basis of this action, T-box proteins are called transcription factors. Genes in the T-box family are grouped together because the proteins produced from these genes share a similar segment called a T box. The T box is the part of the protein that binds to DNA. T-box proteins often interact with one another or with other transcription factors that regulate gene activity.
Researchers have identified at least 17 genes in the T-box gene family. Mutations in these genes lead to disorders that involve the abnormal development of tissues in which a particular T-box gene is active (expressed). Many genetic disorders caused by T-box gene mutations are characterized by heart problems and/or skeletal abnormalities of the hands and arms.
(text from Genetics Home Reference http://ghr.nlm.nih.gov/geneFamily/tbx)
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
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Limb Development
Mouse forelimb bud Tbx3 and Tbx2 expression[3]
- Links: Limb Development
Respiratory Development
Mouse respiratory Tbx4 and Tbx5 model[4]
(Text from figure legend) |
References
- ↑ 1.0 1.1 <pubmed>22174793</pubmed>| PMC3235105 | PLoS One.
- ↑ <pubmed>22371266</pubmed>
- ↑ <pubmed>20386744</pubmed>| PLoS Genet.
- ↑ <pubmed>22876201</pubmed>| PLoS Genet.
Search Bookshelf Tbx
Reviews
<pubmed>17506689</pubmed> <pubmed>10197584</pubmed>
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- OMIM - http://omim.org/entry/602054
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Cite this page: Hill, M.A. (2024, March 28) Embryology Developmental Signals - Tbx. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Tbx
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G