Developmental Signals - Tbx: Difference between revisions
No edit summary |
No edit summary |
||
Line 1: | Line 1: | ||
==Introduction== | ==Introduction== | ||
[[File:Mouse_Tbx5.jpg| | [[File:Mouse_Tbx5.jpg|thumbMouse forelimb Tbx5 expression.<ref name=PMID22174793><pubmed>22174793</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235105 PMC3235105] | [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0028358 PLoS One.]</ref>]] | ||
</ref> | |||
[[File:Mouse_Tbx4.jpg|thumbMouse hindlimb Tbx4 expression.<ref name=PMID22174793><pubmed>22174793</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235105 PMC3235105] | [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0028358 PLoS One.]</ref>]] | |||
::''Draft Page.'' | ::''Draft Page.'' | ||
Revision as of 16:26, 13 February 2013
Introduction
- Draft Page.
Genes in the TBX gene family provide instructions for making proteins called T-box proteins that play critical roles during embryonic development. These proteins are especially important for normal development of the arms, hands, and heart. T-box proteins regulate the activity of other genes by attaching (binding) to specific regions of DNA. On the basis of this action, T-box proteins are called transcription factors. Genes in the T-box family are grouped together because the proteins produced from these genes share a similar segment called a T box. The T box is the part of the protein that binds to DNA. T-box proteins often interact with one another or with other transcription factors that regulate gene activity.
Researchers have identified at least 17 genes in the T-box gene family. Mutations in these genes lead to disorders that involve the abnormal development of tissues in which a particular T-box gene is active (expressed). Many genetic disorders caused by T-box gene mutations are characterized by heart problems and/or skeletal abnormalities of the hands and arms.
(text from Genetics Home Reference http://ghr.nlm.nih.gov/geneFamily/tbx)
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
References
- ↑ 1.0 1.1 <pubmed>22174793</pubmed>| PMC3235105 | PLoS One.
- ↑ <pubmed></pubmed>
Search Bookshelf Pax
Reviews
<pubmed>17506689</pubmed> <pubmed>10197584</pubmed>
Search Pubmed
Search Pubmed Now: Tbx
http://www.ncbi.nlm.nih.gov/omim
External Links
- OMIM - Pax6
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, March 28) Embryology Developmental Signals - Tbx. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Tbx
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G