Developmental Signals - Tbx: Difference between revisions

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==Introduction==
==Introduction==
[[File:Mouse_Tbx5.jpg|Mouse forelimb Tbx5 expression.<ref name=PMID22174793><pubmed>22174793</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235105 PMC3235105] | [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0028358 PLoS One.]
[[File:Mouse_Tbx5.jpg|thumbMouse forelimb Tbx5 expression.<ref name=PMID22174793><pubmed>22174793</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235105 PMC3235105] | [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0028358 PLoS One.]</ref>]]
</ref>
 
[[File:Mouse_Tbx4.jpg|thumbMouse hindlimb Tbx4 expression.<ref name=PMID22174793><pubmed>22174793</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235105 PMC3235105] | [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0028358 PLoS One.]</ref>]]
 
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Revision as of 16:26, 13 February 2013

Introduction

thumbMouse forelimb Tbx5 expression.[1]

thumbMouse hindlimb Tbx4 expression.[1]

Draft Page.

Genes in the TBX gene family provide instructions for making proteins called T-box proteins that play critical roles during embryonic development. These proteins are especially important for normal development of the arms, hands, and heart. T-box proteins regulate the activity of other genes by attaching (binding) to specific regions of DNA. On the basis of this action, T-box proteins are called transcription factors. Genes in the T-box family are grouped together because the proteins produced from these genes share a similar segment called a T box. The T box is the part of the protein that binds to DNA. T-box proteins often interact with one another or with other transcription factors that regulate gene activity.

Researchers have identified at least 17 genes in the T-box gene family. Mutations in these genes lead to disorders that involve the abnormal development of tissues in which a particular T-box gene is active (expressed). Many genetic disorders caused by T-box gene mutations are characterized by heart problems and/or skeletal abnormalities of the hands and arms.


(text from Genetics Home Reference http://ghr.nlm.nih.gov/geneFamily/tbx)


Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular

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References

  1. 1.0 1.1 <pubmed>22174793</pubmed>| PMC3235105 | PLoS One.
  2. <pubmed></pubmed>

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<pubmed>17506689</pubmed> <pubmed>10197584</pubmed>

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Cite this page: Hill, M.A. (2024, March 28) Embryology Developmental Signals - Tbx. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Tbx

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G