Developmental Signals - TGF-beta: Difference between revisions
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==Introduction== | ==Introduction== | ||
Transforming Growth Factor-beta (TGF-β) | |||
[[File:TGF-beta signaling pathway.jpg|thumb|TGF-beta signaling pathway<ref>Pang K, Ryan JF, Baxevanis AD, Martindale MQ (2011) '''Evolution of the TGF-β Signaling Pathway and Its Potential Role in the Ctenophore, Mnemiopsis leidyi.''' PLoS ONE 6(9): e24152 [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0024152 PLoS ONE]</ref> | [[File:TGF-beta signaling pathway.jpg|thumb|TGF-beta signaling pathway<ref>Pang K, Ryan JF, Baxevanis AD, Martindale MQ (2011) '''Evolution of the TGF-β Signaling Pathway and Its Potential Role in the Ctenophore, Mnemiopsis leidyi.''' PLoS ONE 6(9): e24152 [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0024152 PLoS ONE]</ref> | ||
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* <ref name="PMID20227380"><pubmed>20227380</pubmed></ref> | * <ref name="PMID20227380"><pubmed>20227380</pubmed></ref> | ||
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==Structure== | |||
The precursor protein has three distinct regions: | |||
# '''signal peptide''' - targets it to the endoplasmic reticulum and secretion | |||
# '''propeptide''' - or the latency associated peptide | |||
# '''mature peptide''' - cleaved from the precursor protein and is actively involved in signalling | |||
==Function== | ==Function== | ||
Revision as of 16:06, 10 September 2011
Introduction
Transforming Growth Factor-beta (TGF-β)
| Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
Structure
The precursor protein has three distinct regions:
- signal peptide - targets it to the endoplasmic reticulum and secretion
- propeptide - or the latency associated peptide
- mature peptide - cleaved from the precursor protein and is actively involved in signalling
Function
Signaling Pathway
(data from Expasy)
OMIM
About OMIM "Online Mendelian Inheritance in Man OMIM is a comprehensive, authoritative, and timely compendium of human genes and genetic phenotypes. The full-text, referenced overviews in OMIM contain information on all known mendelian disorders and over 12,000 genes. OMIM focuses on the relationship between phenotype and genotype. It is updated daily, and the entries contain copious links to other genetics resources." OMIM
References
Reviews
Articles
<pubmed>17077151</pubmed>
Search PubMed: TGF-beta
External Links
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Glossary Links
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Cite this page: Hill, M.A. (2024, April 18) Embryology Developmental Signals - TGF-beta. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_TGF-beta
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
