Developmental Signals - Sox

From Embryology

Introduction

The SRY (480000) and SOX proteins share a DNA-binding domain known as the HMG box, defined by a 79-amino acid region. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 (184429), and SOX3 (313430) show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse (Collignon et al., 1996). These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution.

Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular

Some Recent Findings

  • Sox2 is essential for formation of trophectoderm in the preimplantation embryo[1] "In preimplantation mammalian development the transcription factor Sox2 (SRY-related HMG-box gene 2) forms a complex with Oct4 and functions in maintenance of self-renewal of the pluripotent inner cell mass (ICM). ...We conclude that the first essential function of Sox2 in the preimplantation mouse embryo is to facilitate establishment of the trophectoderm lineage. Our findings provide a novel insight into the first differentiation event within the preimplantation embryo, namely the segregation of the ICM and TE lineages."

Early Mouse Expression

Mouse Sox2 expression 01.jpg

Mouse Sox2 expression 02.jpg

Mouse Sox2 expression 03.jpg

Function

Respiratory Development

Sox2

  • regulates patterning of the anterior foregut into ventral (trachea) and dorsal (esophagus) fates
  • endoderm expression during formation of foregut derivatives
  • declines in regions undergoing lung bud morphogenesis
  • declines in ventral region generating the trachea


Links: Respiratory System Development | StemBook - Specification and patterning of the respiratory system

Signaling Pathway

(data from Expasy)

OMIM

About OMIM "Online Mendelian Inheritance in Man OMIM is a comprehensive, authoritative, and timely compendium of human genes and genetic phenotypes. The full-text, referenced overviews in OMIM contain information on all known mendelian disorders and over 12,000 genes. OMIM focuses on the relationship between phenotype and genotype. It is updated daily, and the entries contain copious links to other genetics resources." OMIM


References

  1. <pubmed>21103067</pubmed>| PMC2980489 | PLoS One.

Reviews

<pubmed>17584862</pubmed>

Search PubMed: Sox

External Links

The nature of the internet is that some links may change over time. If the link no longer functions, search the internet using the link term.



Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Cite this page: Hill, M.A. (2024, March 29) Embryology Developmental Signals - Sox. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Sox

What Links Here?
© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G