Developmental Signals - Sox: Difference between revisions
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==Limb Expression== | |||
[[File:Limb patterning factors 05.jpg]] | |||
Sox9 expression in E12.5 wild-type mouse embryonic forelimb.<ref><pubmed>17194222</pubmed>| [http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1713256 PMC1713256] | [http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.0020216 PLoS Genet.]</ref> | |||
==Function== | ==Function== |
Revision as of 16:34, 10 May 2012
Introduction
The SRY (480000) and SOX proteins share a DNA-binding domain known as the HMG box, defined by a 79-amino acid region. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 (184429), and SOX3 (313430) show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse (Collignon et al., 1996). These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution.
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
|
Early Mouse Expression
Limb Expression
Sox9 expression in E12.5 wild-type mouse embryonic forelimb.[3]
Function
Respiratory Development
Sox2
- regulates patterning of the anterior foregut into ventral (trachea) and dorsal (esophagus) fates
- endoderm expression during formation of foregut derivatives
- declines in regions undergoing lung bud morphogenesis
- declines in ventral region generating the trachea
- Links: Respiratory System Development | StemBook - Specification and patterning of the respiratory system
Signaling Pathway
(data from Expasy)
OMIM
About OMIM "Online Mendelian Inheritance in Man OMIM is a comprehensive, authoritative, and timely compendium of human genes and genetic phenotypes. The full-text, referenced overviews in OMIM contain information on all known mendelian disorders and over 12,000 genes. OMIM focuses on the relationship between phenotype and genotype. It is updated daily, and the entries contain copious links to other genetics resources." OMIM
References
- ↑ <pubmed>20704721</pubmed>| BMC Dev Biol.
- ↑ <pubmed>21103067</pubmed>| PMC2980489 | PLoS One.
- ↑ <pubmed>17194222</pubmed>| PMC1713256 | PLoS Genet.
Reviews
<pubmed>17584862</pubmed>
Search PubMed: Sox
External Links
The nature of the internet is that some links may change over time. If the link no longer functions, search the internet using the link term.
Glossary Links
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Cite this page: Hill, M.A. (2024, April 20) Embryology Developmental Signals - Sox. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Sox
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G