Developmental Signals - Sox: Difference between revisions

Revision as of 11:50, 10 October 2012

Introduction

Mouse (E10.5) Sox10 expression^[1]

The SRY (480000) and SOX proteins share a DNA-binding domain known as the HMG box, defined by a 79-amino acid region. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 (184429), and SOX3 (313430) show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse (Collignon et al., 1996). These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution.

Sox2 is first expressed in very early (morula, blastocyst) development, and has also been identified as one of the 4 "Yamanaka Factors" required to generate an induced pluripotential stem cell (iPS cell). It also forms a trimeric complex with OCT4, yet another "Yamanaka Factor".

Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular

Some Recent Findings

Sox2 is essential for formation of trophectoderm in the preimplantation embryo^[2] "In preimplantation mammalian development the transcription factor Sox2 (SRY-related HMG-box gene 2) forms a complex with Oct4 and functions in maintenance of self-renewal of the pluripotent inner cell mass (ICM). ...We conclude that the first essential function of Sox2 in the preimplantation mouse embryo is to facilitate establishment of the trophectoderm lineage. Our findings provide a novel insight into the first differentiation event within the preimplantation embryo, namely the segregation of the ICM and TE lineages."

Early Mouse Expression

Limb Expression

Sox9 expression in E12.5 wild-type mouse embryonic forelimb.^[3]

Function

Respiratory Development

Sox2

regulates patterning of the anterior foregut into ventral (trachea) and dorsal (esophagus) fates
endoderm expression during formation of foregut derivatives
declines in regions undergoing lung bud morphogenesis
declines in ventral region generating the trachea

Links: Respiratory System Development | StemBook - Specification and patterning of the respiratory system

Signaling Pathway

(data from Expasy)

OMIM

Sox 1

About OMIM "Online Mendelian Inheritance in Man OMIM is a comprehensive, authoritative, and timely compendium of human genes and genetic phenotypes. The full-text, referenced overviews in OMIM contain information on all known mendelian disorders and over 12,000 genes. OMIM focuses on the relationship between phenotype and genotype. It is updated daily, and the entries contain copious links to other genetics resources." OMIM

References

↑ <pubmed>20704721</pubmed>| BMC Dev Biol.
↑ <pubmed>21103067</pubmed>| PMC2980489 | PLoS One.
↑ <pubmed>17194222</pubmed>| PMC1713256 | PLoS Genet.

Reviews

Search PubMed: Sox

External Links

The nature of the internet is that some links may change over time. If the link no longer functions, search the internet using the link term.

Glossary Links

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Cite this page: Hill, M.A. (2024, April 19) Embryology Developmental Signals - Sox. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Sox

What Links Here?

[1] <pubmed>20704721</pubmed>| BMC Dev Biol.

[PMID21103067-2] <pubmed>21103067</pubmed>| PMC2980489 | PLoS One.

[3] <pubmed>17194222</pubmed>| PMC1713256 | PLoS Genet.

[1]

[2]

[3]

Revision as of 11:48, 10 October 2012 (view source) Z8600021 (talk \| contribs) (→‎Introduction) ← Older edit		Revision as of 11:50, 10 October 2012 (view source) Z8600021 (talk \| contribs) (→‎Introduction) Newer edit →
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	The SRY (480000) and SOX proteins share a DNA-binding domain known as the HMG box, defined by a 79-amino acid region. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 (184429), and SOX3 (313430) show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse (Collignon et al., 1996). These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution.		The SRY (480000) and SOX proteins share a DNA-binding domain known as the HMG box, defined by a 79-amino acid region. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 (184429), and SOX3 (313430) show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse (Collignon et al., 1996). These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution.

	Sox2 is first expressed in very early (morula, blastocyst) development, and has also been identified as one of the 4 "Yamanaka Factors" required to generate an induced pluripotential stem cell (iPS cell).		Sox2 is first expressed in very early (morula, blastocyst) development, and has also been identified as one of the 4 "Yamanaka Factors" required to generate an induced pluripotential stem cell (iPS cell). It also forms a trimeric complex with OCT4, yet another "Yamanaka Factor".