Developmental Signals - Six

Embryology - 19 Apr 2024 Expand to Translate
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Introduction

Sine oculis-related homeobox (Six) is a homeobox gene family. In humans, mutations of SIX1 cause branchio-oto-renal (BOR) syndrome, an autosomal dominant disorder characterized by hearing loss, pharyngeal arch defects and various renal abnormalities.

Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular

Some Recent Findings

Activation of Six1 Expression in Vertebrate Sensory Neurons^[1] "SIX1 homeodomain protein is one of the essential key regulators of sensory organ development. Six1-deficient mice lack the olfactory epithelium, vomeronasal organs, cochlea, vestibule and vestibuloacoustic ganglion, and also show poor neural differentiation in the distal part of the cranial ganglia. Simultaneous loss of both Six1 and Six4 leads to additional abnormalities such as small trigeminal ganglion and abnormal dorsal root ganglia (DRG)."

More recent papers
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link. This search now requires a manual link as the original PubMed extension has been disabled. The displayed list of references do not reflect any editorial selection of material based on content or relevance. References also appear on this list based upon the date of the actual page viewing. References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability. More? References \| Discussion Page \| Journal Searches \| 2019 References \| 2020 References Search term: Development Six <pubmed limit=5>Development Six</pubmed>

Transcription Factor

Neural Development

Vision Development

Abnormalities

References

↑ <pubmed>26313368</pubmed>

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http://www.ncbi.nlm.nih.gov/omim

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OMIM - Six1

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Cite this page: Hill, M.A. (2024, April 19) Embryology Developmental Signals - Six. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Six

What Links Here?

[PMID26313368-1] <pubmed>26313368</pubmed>

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