Developmental Signals - Notch: Difference between revisions
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* '''Transitions in cell potency during early mouse development are driven by Notch'''{{#pmid:30958266|PMID30958266}} "The Notch signalling pathway plays fundamental roles in diverse developmental processes in metazoans, where it is important in driving cell fate and directing differentiation of various cell types. However, we still have limited knowledge about the role of Notch in early preimplantation stages of mammalian development, or how it interacts with other signalling pathways active at these stages such as Hippo. By using genetic and pharmacological tools in vivo, together with image analysis of single embryos and pluripotent cell culture, we have found that Notch is active from the 4-cell stage. Transcriptomic analysis in single morula identified novel Notch targets, such as early naïve pluripotency markers or transcriptional repressors such as TLE4. Our results reveal a previously undescribed role for Notch in driving transitions during the gradual loss of potency that takes place in the early mouse embryo prior to the first lineage decisions." | |||
* '''Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning'''{{#pmid:27226324|PMID27226324}} "Coordinating cell differentiation with cell growth and division is crucial for the successful development, homeostasis and regeneration of multicellular tissues. Here, we use bristle patterning in the fly notum as a model system to explore the regulatory and functional coupling of cell cycle progression and cell fate decision-making. The pattern of bristles and intervening epithelial cells (ECs) becomes established through Notch-mediated lateral inhibition during G2 phase of the cell cycle, as neighbouring cells physically interact with each other via lateral contacts and/or basal protrusions. Since Notch signalling controls cell division timing downstream of Cdc25, ECs in lateral contact with a Delta-expressing cell experience higher levels of Notch signalling and divide first, followed by more distant neighbours, and lastly Delta-expressing cells. Conversely, mitotic entry and cell division makes ECs refractory to lateral inhibition signalling, fixing their fate. Using a combination of experiments and computational modelling, we show that this reciprocal relationship between Notch signalling and cell cycle progression acts like a developmental clock, providing a delimited window of time during which cells decide their fate, ensuring efficient and orderly bristle patterning." | * '''Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning'''{{#pmid:27226324|PMID27226324}} "Coordinating cell differentiation with cell growth and division is crucial for the successful development, homeostasis and regeneration of multicellular tissues. Here, we use bristle patterning in the fly notum as a model system to explore the regulatory and functional coupling of cell cycle progression and cell fate decision-making. The pattern of bristles and intervening epithelial cells (ECs) becomes established through Notch-mediated lateral inhibition during G2 phase of the cell cycle, as neighbouring cells physically interact with each other via lateral contacts and/or basal protrusions. Since Notch signalling controls cell division timing downstream of Cdc25, ECs in lateral contact with a Delta-expressing cell experience higher levels of Notch signalling and divide first, followed by more distant neighbours, and lastly Delta-expressing cells. Conversely, mitotic entry and cell division makes ECs refractory to lateral inhibition signalling, fixing their fate. Using a combination of experiments and computational modelling, we show that this reciprocal relationship between Notch signalling and cell cycle progression acts like a developmental clock, providing a delimited window of time during which cells decide their fate, ensuring efficient and orderly bristle patterning." | ||
* '''Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors'''{{#pmid:25564622|PMID25564622}} "Basal cells are multipotent airway progenitors that generate distinct epithelial cell phenotypes crucial for homeostasis and repair of the conducting airways. Little is known about how these progenitor cells expand and transition to differentiation to form the pseudostratified airway epithelium in the developing and adult lung. Here, we show by genetic and pharmacological approaches that endogenous activation of Notch3 signaling selectively controls the pool of undifferentiated progenitors of upper airways available for differentiation. This mechanism depends on the availability of Jag1 and Jag2, and is key to generating a population of parabasal cells that later activates Notch1 and Notch2 for secretory-multiciliated cell fate selection." [[Respiratory System Development]] | * '''Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors'''{{#pmid:25564622|PMID25564622}} "Basal cells are multipotent airway progenitors that generate distinct epithelial cell phenotypes crucial for homeostasis and repair of the conducting airways. Little is known about how these progenitor cells expand and transition to differentiation to form the pseudostratified airway epithelium in the developing and adult lung. Here, we show by genetic and pharmacological approaches that endogenous activation of Notch3 signaling selectively controls the pool of undifferentiated progenitors of upper airways available for differentiation. This mechanism depends on the availability of Jag1 and Jag2, and is key to generating a population of parabasal cells that later activates Notch1 and Notch2 for secretory-multiciliated cell fate selection." [[Respiratory System Development]] | ||
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* '''Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb'''{{#pmid:24927569|PMID24927569}} "Multipotent Pax3-positive (Pax3(+)) cells in the somites give rise to skeletal muscle and to cells of the vasculature. We had previously proposed that this cell-fate choice depends on the equilibrium between Pax3 and Foxc2 expression. In this study, we report that the Notch pathway promotes vascular versus skeletal muscle cell fates. ...We now demonstrate that in addition to the inhibitory role of Notch signaling on skeletal muscle cell differentiation, the Notch pathway affects the Pax3:Foxc2 balance and promotes the endothelial versus myogenic cell fate, before migration to the limb, in multipotent Pax3(+) cells in the somite of the mouse embryo." [[Musculoskeletal_System_-_Limb_Development|Limb Development]] | [[Musculoskeletal_System_-_Muscle_Development|Muscle Development]] | |||
* '''The precise timeline of transcriptional regulation reveals causation in mouse somitogenesis network'''{{#pmid:24304493|PMID24304493}} "In vertebrate development, the segmental pattern of the body axis is established as somites, masses of mesoderm distributed along the two sides of the neural tube, are formed sequentially in the anterior-posterior axis. This mechanism depends on waves of gene expression associated with the Notch, Fgf and Wnt pathways." | * '''The precise timeline of transcriptional regulation reveals causation in mouse somitogenesis network'''{{#pmid:24304493|PMID24304493}} "In vertebrate development, the segmental pattern of the body axis is established as somites, masses of mesoderm distributed along the two sides of the neural tube, are formed sequentially in the anterior-posterior axis. This mechanism depends on waves of gene expression associated with the Notch, Fgf and Wnt pathways." | ||
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==Functions== | ==Functions== | ||
Developmental patterning signal. | Developmental patterning signal. | ||
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{{Blastocyst Hippo table}} | {{Blastocyst Hippo table}} | ||
===Spinal Cord Development=== | ===Neural=== | ||
====Spinal Cord Development==== | |||
{| | {| | ||
| Model of the embryonic rostro-caudal gradient of neurogenesis along the chicken spinal cord from the stem zone to the neurogenic neural tube summarising how DELTA-NOTCH signalling may be involved in these processes.{{#pmid:18000541|PMID18000541}} | | Model of the embryonic rostro-caudal gradient of neurogenesis along the chicken spinal cord from the stem zone to the neurogenic neural tube summarising how DELTA-NOTCH signalling may be involved in these processes.{{#pmid:18000541|PMID18000541}} | ||
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| [[File:Spinal cord delta notch model.png|500px]] | | [[File:Spinal cord delta notch model.png|500px]] | ||
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====Hippocampus==== | |||
'''Notch1 deficiency in postnatal neural progenitor cells in the dentate gyrus leads to emotional and cognitive impairment'''{{#pmid:28611114|PMID28611114}} | |||
:"The latest evidence shows that Notch1 also plays a critical role in synaptic plasticity in mature hippocampal neurons. So far, deeper insights into the function of Notch1 signaling during the different steps of adult neurogenesis are still lacking, and the mechanisms by which Notch1 dysfunction is associated with brain disorders are also poorly understood. In the current study, we found that Notch1 was highly expressed in the adult-born immature neurons in the hippocampal dentate gyrus. Using a genetic approach to selectively ablate Notch1 signaling in late immature precursors in the postnatal hippocampus by cross-breeding doublecortin (DCX)+ neuron-specific proopiomelanocortin (POMC)-α Cre mice with floxed Notch1 mice, we demonstrated a previously unreported pivotal role of Notch1 signaling in survival and function of adult newborn neurons in the dentate gyrus. Moreover, behavioral and functional studies demonstrated that POMC-Notch1-/- mutant mice showed anxiety and depressive-like behavior with impaired synaptic transmission properties in the dentate gyrus. Finally, our mechanistic study showed significantly compromised phosphorylation of cAMP response element-binding protein (CREB) in Notch1 mutants, suggesting that the dysfunction of Notch1 mutants is associated with the disrupted pCREB signaling in postnatally generated immature neurons in the dentate gyrus." | |||
:'''Links:''' [[Neural - Hippocampus Development|Hippocampus Development]] | |||
===Endoderm Development=== | ===Endoderm Development=== | ||
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===Reviews=== | ===Reviews=== | ||
{{#pmid:32072495}} | |||
{{#pmid:23165243}} | {{#pmid:23165243}} | ||
Latest revision as of 15:45, 9 March 2020
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Introduction
The notch proteins were first identified in drosophila development and have since been identified as regulators of cell fate decisions during development. These are a family of cell surface transmembrane receptors that pass once through the plasma membrane.
This signalling pathway is involved with many different developmental patterning pathways and in the adult is a key regulator in the vascular system.
- Notch Links: Notch structure cartoon | Notch signaling pathway cartoon | Notch and signaling pathway cartoon | Developmental Signals - Notch | Molecular Factors
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Notch |
Older papers |
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These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
See also the Discussion Page for other references listed by year and References on this current page.
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Notch Signaling
Notch signaling pathway[1] |
(text from original figure legend) |
Notch Receptors
Notch receptors belong to the Ankyrin repeat domain containing (ANKRD) gene family (242 members).
Table - Human Notch Family (Ankyrin repeat domain - ANKRD) | |||||
Approved Symbol |
Approved Name | Previous Symbols |
Synonyms | Chromosome | OMIM ID |
---|---|---|---|---|---|
NOTCH1 | notch 1 | TAN1 | 9q34.3 | 190198 | |
NOTCH2 | notch 2 | 1p12 | 600275 | ||
NOTCH3 | notch 3 | CADASIL | CASIL | 19p13.12 | 600276 |
NOTCH4 | notch 4 | INT3 | 6p21.32 | 164951 | |
Links: Notch | OMIM BMP2 | HGNC - ANKRD | Bmp Family | Notch Family | Sox Family | Tbx Family |
Human BMP Family | ||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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NOTCH3
- Notch3 activation retains mammary luminal cell in a nonproliferative state [10]
NOTCH4
Notch Ligands
- JAG1
- JAG2
- DLL1
- DLL3
- DLL4
Functions
Developmental patterning signal.
Early Development
Blastocyst
Mouse Blastocyst (32 cell stage) Fate | |
---|---|
Inner cells | Outer cells |
Angiomotin (Amot) phosphorylation at adherens junctions | Amot sequestered by cell polarization from basolateral adherens junctions |
Hippo active | Hippo inactive |
Notch inactive | Notch active |
Cdx2 not expressed | Cdx2 expressed |
ICM - inner cell mass fate | TE - trophectoderm fate |
Hippo[11](TEAD4) and Notch[12](Cdx2) together appear regulate early blastocyst fate development. |
Neural
Spinal Cord Development
Model of the embryonic rostro-caudal gradient of neurogenesis along the chicken spinal cord from the stem zone to the neurogenic neural tube summarising how DELTA-NOTCH signalling may be involved in these processes.[13]
|
Hippocampus
Notch1 deficiency in postnatal neural progenitor cells in the dentate gyrus leads to emotional and cognitive impairment[14]
- "The latest evidence shows that Notch1 also plays a critical role in synaptic plasticity in mature hippocampal neurons. So far, deeper insights into the function of Notch1 signaling during the different steps of adult neurogenesis are still lacking, and the mechanisms by which Notch1 dysfunction is associated with brain disorders are also poorly understood. In the current study, we found that Notch1 was highly expressed in the adult-born immature neurons in the hippocampal dentate gyrus. Using a genetic approach to selectively ablate Notch1 signaling in late immature precursors in the postnatal hippocampus by cross-breeding doublecortin (DCX)+ neuron-specific proopiomelanocortin (POMC)-α Cre mice with floxed Notch1 mice, we demonstrated a previously unreported pivotal role of Notch1 signaling in survival and function of adult newborn neurons in the dentate gyrus. Moreover, behavioral and functional studies demonstrated that POMC-Notch1-/- mutant mice showed anxiety and depressive-like behavior with impaired synaptic transmission properties in the dentate gyrus. Finally, our mechanistic study showed significantly compromised phosphorylation of cAMP response element-binding protein (CREB) in Notch1 mutants, suggesting that the dysfunction of Notch1 mutants is associated with the disrupted pCREB signaling in postnatally generated immature neurons in the dentate gyrus."
- Links: Hippocampus Development
Endoderm Development
Endoderm differentiates to form the respiratory airway epithelium and glands. This epithelium is continuously replaced through life from a basal cell pool of undifferentiated airway progenitors. A recent study[5] has shown that the progenitor pool is regulated by the Notch3-Jagged signaling pathway. The mechanism appears dependent upon the availability of Jag1 and Jag2 (generating parabasal cells) that later activates Notch1 and Notch2 leading to a secretory-multiciliated cell fate.
- L;inks: Respiratory System Development
Mesoderm Development
Blood Vessel Development
NOTCH Signaling in the EndotheliumPubmedParser error: Invalid PMID, please check. (PMID: 29547401PMID29547401)
(a) A vascular sprout is characterized by a leading ‘tip’ cell followed by ‘stalk’ cells.
(b) Regulation of new sprouting during vascular expansion depends on integration of BMP signaling, NOTCH signaling and VEGF signaling.
(c) In adult vessels, NOTCH is responsible for maintaining endothelial quiescence and junctional integrity.
Muscle Regeneration
Notch signalling in muscle regeneration[15]
Hypothalamus Development
Hypothalamus Development Gene Interaction Model[16]
- Links: Hypothalamus Development
Abnormalities
Alagille Syndrome
Mutations in the human homolog of Jagged-1 (JAG1) located on chromosome 20p12 cause Alagille Syndrome. Abnormalities are seen in gastrointestinal (liver cholestasis), cardiac (heart), renal (kidney), skeletal, ocular, and facial systems.
- Links: Alagille Syndrome
References
- ↑ 1.0 1.1 Tien AC, Rajan A & Bellen HJ. (2009). A Notch updated. J. Cell Biol. , 184, 621-9. PMID: 19255248 DOI.
- ↑ 2.0 2.1 Fongang B & Kudlicki A. (2013). The precise timeline of transcriptional regulation reveals causation in mouse somitogenesis network. BMC Dev. Biol. , 13, 42. PMID: 24304493 DOI.
- ↑ Menchero S, Rollan I, Lopez-Izquierdo A, Andreu MJ, Sainz de Aja J, Kang M, Adan J, Benedito R, Rayon T, Hadjantonakis AK & Manzanares M. (2019). Transitions in cell potency during early mouse development are driven by Notch. Elife , 8, . PMID: 30958266 DOI.
- ↑ Hunter GL, Hadjivasiliou Z, Bonin H, He L, Perrimon N, Charras G & Baum B. (2016). Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning. Development , 143, 2305-10. PMID: 27226324 DOI.
- ↑ 5.0 5.1 Mori M, Mahoney JE, Stupnikov MR, Paez-Cortez JR, Szymaniak AD, Varelas X, Herrick DB, Schwob J, Zhang H & Cardoso WV. (2015). Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors. Development , 142, 258-67. PMID: 25564622 DOI.
- ↑ Mayeuf-Louchart A, Lagha M, Danckaert A, Rocancourt D, Relaix F, Vincent SD & Buckingham M. (2014). Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb. Proc. Natl. Acad. Sci. U.S.A. , 111, 8844-9. PMID: 24927569 DOI.
- ↑ Schrauwen I & Van Camp G. (2010). The etiology of otosclerosis: a combination of genes and environment. Laryngoscope , 120, 1195-202. PMID: 20513039 DOI.
- ↑ 8.0 8.1 Mead TJ & Yutzey KE. (2009). Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development. Proc. Natl. Acad. Sci. U.S.A. , 106, 14420-5. PMID: 19590010 DOI.
- ↑ Schuster-Gossler K, Harris B, Johnson KR, Serth J & Gossler A. (2009). Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse development. BMC Dev. Biol. , 9, 6. PMID: 19161597 DOI.
- ↑ Lafkas D, Rodilla V, Huyghe M, Mourao L, Kiaris H & Fre S. (2013). Notch3 marks clonogenic mammary luminal progenitor cells in vivo. J. Cell Biol. , 203, 47-56. PMID: 24100291 DOI.
- ↑ Sasaki H. (2015). Position- and polarity-dependent Hippo signaling regulates cell fates in preimplantation mouse embryos. Semin. Cell Dev. Biol. , 47-48, 80-7. PMID: 25986053 DOI.
- ↑ Rayon T, Menchero S, Nieto A, Xenopoulos P, Crespo M, Cockburn K, Cañon S, Sasaki H, Hadjantonakis AK, de la Pompa JL, Rossant J & Manzanares M. (2014). Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst. Dev. Cell , 30, 410-22. PMID: 25127056 DOI.
- ↑ Hämmerle B & Tejedor FJ. (2007). A novel function of DELTA-NOTCH signalling mediates the transition from proliferation to neurogenesis in neural progenitor cells. PLoS ONE , 2, e1169. PMID: 18000541 DOI.
- ↑ Feng S, Shi T, Qiu J, Yang H, Wu Y, Zhou W, Wang W & Wu H. (2017). Notch1 deficiency in postnatal neural progenitor cells in the dentate gyrus leads to emotional and cognitive impairment. FASEB J. , 31, 4347-4358. PMID: 28611114 DOI.
- ↑ Mourikis P & Tajbakhsh S. (2014). Distinct contextual roles for Notch signalling in skeletal muscle stem cells. BMC Dev. Biol. , 14, 2. PMID: 24472470 DOI.
- ↑ Ratié L, Ware M, Barloy-Hubler F, Romé H, Gicquel I, Dubourg C, David V & Dupé V. (2013). Novel genes upregulated when NOTCH signalling is disrupted during hypothalamic development. Neural Dev , 8, 25. PMID: 24360028 DOI.
Reviews
Reichrath J & Reichrath S. (2020). A Snapshot of the Molecular Biology of Notch Signaling: Challenges and Promises. Adv. Exp. Med. Biol. , 1227, 1-7. PMID: 32072495 DOI.
Amelio I, Grespi F, Annicchiarico-Petruzzelli M & Melino G. (2012). p63 the guardian of human reproduction. Cell Cycle , 11, 4545-51. PMID: 23165243 DOI.
Roemer K. (2012). Notch and the p53 clan of transcription factors. Adv. Exp. Med. Biol. , 727, 223-40. PMID: 22399351 DOI.
Andersen P, Uosaki H, Shenje LT & Kwon C. (2012). Non-canonical Notch signaling: emerging role and mechanism. Trends Cell Biol. , 22, 257-65. PMID: 22397947 DOI.
Andersson ER, Sandberg R & Lendahl U. (2011). Notch signaling: simplicity in design, versatility in function. Development , 138, 3593-612. PMID: 21828089 DOI.
Articles
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Cite this page: Hill, M.A. (2024, April 25) Embryology Developmental Signals - Notch. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Notch
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