Developmental Signals - Nodal

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Introduction

Notch structure cartoon
Notch structure cartoon[1]

The nodal proteins were first identified in drosophila development and have since been identified as regulators of cell fate decisions during development. These are a family of cell surface transmembrane receptors that pass once through the plasma membrane.


Notch Links: Notch structure cartoon | Notch signaling pathway cartoon | Notch and signaling pathway cartoon | Developmental Signals - Notch | Molecular Factors
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular

Some Recent Findings

More recent papers  
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Search term: Nodal

<pubmed limit=5>Nodal</pubmed>

Older papers  
These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.

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Nodal Signaling

Nodal Receptors

Nodal Ligands

Functions

Developmental patterning signal.

Endoderm Development

Endoderm differentiates to form the respiratory airway epithelium and glands. This epithelium is continuously replaced through life from a basal cell pool of undifferentiated airway progenitors. A recent study[3] has shown that the progenitor pool is regulated by the Notch3-Jagged signaling pathway. The mechanism appears dependent upon the availability of Jag1 and Jag2 (generating parabasal cells) that later activates Notch1 and Notch2 leading to a secretory-multiciliated cell fate.

L;inks: Respiratory System Development

Mesoderm Development

Cartilage Development

Hypothalamus Development

Links: Hypothalamus Development

Abnormalities

Links:

References

  1. <pubmed>19255248</pubmed>
  2. <pubmed>27226324</pubmed>
  3. <pubmed>25564622</pubmed>


Reviews

<pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed>

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External Links

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Cite this page: Hill, M.A. (2021, January 23) Embryology Developmental Signals - Nodal. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Nodal

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© Dr Mark Hill 2021, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G