Developmental Signals - Nodal

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Introduction

Notch structure cartoon
Notch structure cartoon[1]

The nodal proteins were first identified in drosophila development and have since been identified as regulators of cell fate decisions during development. These are a family of cell surface transmembrane receptors that pass once through the plasma membrane.


Notch Links: Notch structure cartoon | Notch signaling pathway cartoon | Notch and signaling pathway cartoon | Developmental Signals - Notch | Molecular Factors
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular

Some Recent Findings

More recent papers  
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Search term: Nodal

<pubmed limit=5>Nodal</pubmed>

Older papers  
These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.

See also the Discussion Page for other references listed by year and References on this current page.


Nodal Signaling

Nodal Receptors

Nodal Ligands

Functions

Developmental patterning signal.

Spinal Cord Development

Model of the embryonic rostro-caudal gradient of neurogenesis along the chicken spinal cord from the stem zone to the neurogenic neural tube summarising how DELTA-NOTCH signalling may be involved in these processes.[3]
  • Caudal to rostral decreasing FGF gradient, leads to Delta-1 expression decrease in cells that leave the stem zone (light blue) and move into the PNTZ where they intermingle with cells that do not express Delta-1.
  • Generates differences in DELTA/NOTCH signalling between adjacent cells that may initiate lateral inhibition.
  • Upregulation of Delta-1 in single NP cells which signal (blue arrows) and activate NOTCH signalling in adjacent cells, which as a consequence express Hes5 and are maintained in a proliferating state.
  • Delta-1 expressing NP cell divides into two cells that express Tis21.
  • Double Delta-1/Tis21 labelled NP down regulate the expression of Delta-1 as they reach the NZ and begin to divide in a neurogenic manner.
  • One of the daughter cells upregulates Delta-1 expression and differentiates as a neuron while the other one, which receives NOTCH signalling (blue arrows), remains as neurogenic NP. Hensen node (HN), neural tube (NT), neurogenic zone (NZ), proliferation to neurogenesis transition zone (PNTZ), presomitic territory (PS), somite (S).
Spinal cord delta notch model.png

Endoderm Development

Endoderm differentiates to form the respiratory airway epithelium and glands. This epithelium is continuously replaced through life from a basal cell pool of undifferentiated airway progenitors. A recent study[4] has shown that the progenitor pool is regulated by the Notch3-Jagged signaling pathway. The mechanism appears dependent upon the availability of Jag1 and Jag2 (generating parabasal cells) that later activates Notch1 and Notch2 leading to a secretory-multiciliated cell fate.

L;inks: Respiratory System Development

Mesoderm Development

Cartilage Development

Muscle Regeneration

Notch signalling in muscle regeneration cartoon.jpg

Notch signalling in muscle regeneration[5]

Hypothalamus Development

Hypothalamus gene interaction model.jpg

Hypothalamus Development Gene Interaction Model[6]

Links: Hypothalamus Development

Abnormalities

Alagille Syndrome

Mutations in the human homolog of Jagged-1 (JAG1) located on chromosome 20p12 cause Alagille Syndrome. Abnormalities are seen in gastrointestinal (liver cholestasis), cardiac (heart), renal (kidney), skeletal, ocular, and facial systems.


Links: Alagille Syndrome

References

  1. <pubmed>19255248</pubmed>
  2. <pubmed>27226324</pubmed>
  3. <pubmed>18000541</pubmed>| PLoS ONE
  4. <pubmed>25564622</pubmed>
  5. <pubmed>24472470</pubmed>| BMC Dev Biol.
  6. 24360028<pubmed>24360028</pubmed>| Neural Dev.


Reviews

<pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed>

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Search Bookshelf Nodal

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External Links

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Cite this page: Hill, M.A. (2021, January 24) Embryology Developmental Signals - Nodal. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Nodal

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© Dr Mark Hill 2021, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G