Developmental Signals - Nodal
|Embryology - 24 Jan 2021 Expand to Translate|
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The nodal proteins were first identified in drosophila development and have since been identified as regulators of cell fate decisions during development. These are a family of cell surface transmembrane receptors that pass once through the plasma membrane.
- Notch Links: Notch structure cartoon | Notch signaling pathway cartoon | Notch and signaling pathway cartoon | Developmental Signals - Notch | Molecular Factors
|Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular|
Some Recent Findings
|More recent papers|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
Search term: Nodal
|These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
Developmental patterning signal.
Spinal Cord Development
|Model of the embryonic rostro-caudal gradient of neurogenesis along the chicken spinal cord from the stem zone to the neurogenic neural tube summarising how DELTA-NOTCH signalling may be involved in these processes.
Endoderm differentiates to form the respiratory airway epithelium and glands. This epithelium is continuously replaced through life from a basal cell pool of undifferentiated airway progenitors. A recent study has shown that the progenitor pool is regulated by the Notch3-Jagged signaling pathway. The mechanism appears dependent upon the availability of Jag1 and Jag2 (generating parabasal cells) that later activates Notch1 and Notch2 leading to a secretory-multiciliated cell fate.
- L;inks: Respiratory System Development
Notch signalling in muscle regeneration
Hypothalamus Development Gene Interaction Model
- Links: Hypothalamus Development
Mutations in the human homolog of Jagged-1 (JAG1) located on chromosome 20p12 cause Alagille Syndrome. Abnormalities are seen in gastrointestinal (liver cholestasis), cardiac (heart), renal (kidney), skeletal, ocular, and facial systems.
- Links: Alagille Syndrome
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Search Bookshelf Nodal
Search Pubmed Now: Nodal Signaling
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- OMIM - NOTCH 1
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Cite this page: Hill, M.A. (2021, January 24) Embryology Developmental Signals - Nodal. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Nodal
- © Dr Mark Hill 2021, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G