Developmental Signals - Nodal

Embryology - 24 Apr 2024        Expand to Translate
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Introduction

Notch structure cartoon

The nodal proteins were first identified in drosophila development and have since been identified as regulators of cell fate decisions during development. These are a family of cell surface transmembrane receptors that pass once through the plasma membrane.

Notch Links: Notch structure cartoon | Notch signaling pathway cartoon | Notch and signaling pathway cartoon | Developmental Signals - Notch | Molecular Factors

Some Recent Findings

More recent papers

This table allows an automated computer search of the external PubMed database using the listed "Search term" text link. This search now requires a manual link as the original PubMed extension has been disabled. The displayed list of references do not reflect any editorial selection of material based on content or relevance. References also appear on this list based upon the date of the actual page viewing. References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability. More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Nodal <pubmed limit=5>Nodal</pubmed>

Older papers
These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table. See also the Discussion Page for other references listed by year and References on this current page.

Functions

Developmental patterning signal.

Endoderm Development

Endoderm differentiates to form the respiratory airway epithelium and glands. This epithelium is continuously replaced through life from a basal cell pool of undifferentiated airway progenitors. A recent study has shown that the progenitor pool is regulated by the Notch3-Jagged signaling pathway. The mechanism appears dependent upon the availability of Jag1 and Jag2 (generating parabasal cells) that later activates Notch1 and Notch2 leading to a secretory-multiciliated cell fate.

L;inks: Respiratory System Development

Hypothalamus Development

Links: Hypothalamus Development

Abnormalities

Links:

References

Reviews

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Search Pubmed Now: Nodal Signaling

External Links

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• OMIM - NOTCH 1

Glossary Links

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Cite this page: Hill, M.A. (2024, April 24) Embryology Developmental Signals - Nodal. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Nodal

What Links Here?

© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G