Developmental Signals - Nodal: Difference between revisions

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==Nodal Signaling==
==Nodal Signaling==
Nodal represents a family of transmembrane receptors passing only once through the plasma membrane.
Nodal represents a family of transmembrane receptors passing only once through the plasma membrane. Nodal acts through SMAD2 dependent and independent intracellular pathways.




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Developmental patterning signal.
Developmental patterning signal.


===Mesoderm Development===
===Ectoderm Development===


===Stomach Development===
===Stomach Development===

Revision as of 08:35, 30 April 2017

Embryology - 28 Mar 2024    Facebook link Pinterest link Twitter link  Expand to Translate  
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Introduction

Nodal is a member of the TGF-beta family and together with Lefty both are involved in the initial left-right (L-R) patterning of the axis of the embryo during gastrulation. This patterning signal is later used for many cell fate developmental processes. This patterning role was first established in mouse and zebrafish models, the human homolog was first identified in 1997.[1]


Left-right (L-R) asymmetry include the position on the left side of the heart and spleen and the development of the curvature of the stomach.


Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular

Some Recent Findings

More recent papers  
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Search term: Nodal

<pubmed limit=5>Nodal</pubmed>

Older papers  
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Nodal Signaling

Nodal represents a family of transmembrane receptors passing only once through the plasma membrane. Nodal acts through SMAD2 dependent and independent intracellular pathways.


Nodal Ligands

Functions

Developmental patterning signal.

Ectoderm Development

Stomach Development

  • Stomach curvature is generated by left-right asymmetric gut morphogenesis[3] "Left-right (LR) asymmetry is a fundamental feature of internal anatomy, yet the emergence of morphological asymmetry remains one of the least understood phases of organogenesis. Asymmetric rotation of the intestine is directed by forces outside the gut, but the morphogenetic events that generate anatomical asymmetry in other regions of the digestive tract remain unknown. Here, we show in mouse and Xenopus that the mechanisms that drive the curvature of the stomach are intrinsic to the gut tube itself. The left wall of the primitive stomach expands more than the right wall, as the left epithelium becomes more polarized and undergoes radial rearrangement. These asymmetries exist across several species, and are dependent on LR patterning genes, including Foxj1, Nodal and Pitx2 Our findings have implications for how LR patterning manifests distinct types of morphological asymmetries in different contexts."


Abnormalities

Links:

References

  1. <pubmed>9354794</pubmed>
  2. <pubmed>27226324</pubmed>
  3. <pubmed>28242610</pubmed>


Reviews

<pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed>

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Cite this page: Hill, M.A. (2024, March 28) Embryology Developmental Signals - Nodal. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Nodal

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G