Difference between revisions of "Developmental Signals - Nodal"

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{{Header}}
 
{{Header}}
 
==Introduction==
 
==Introduction==
[[File:Notch structure cartoon.jpg|thumb|350px|alt=Notch structure cartoon|Notch structure cartoon<ref name=PMID19255248><pubmed>19255248</pubmed></ref>]]
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Nodal together with Lefty are involved in the initial left-right (L-R) patterning of the axis of the embryo. This patterning signal is later used for many cell fate developmental processes.
The nodal proteins were first identified in drosophila development and have since been identified as regulators of cell fate decisions during development. These are a family of cell surface transmembrane receptors that pass once through the plasma membrane.
 
  
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Left-right (L-R) asymmetry include the position on the left side of the heart and spleen and the development of the curvature of the stomach.
  
{{Notch links}}
 
  
 
{{Factor Links}}
 
{{Factor Links}}
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==Nodal Signaling==
 
==Nodal Signaling==
 
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Nodal represents a family of transmembrane receptors passing only once through the plasma membrane.
==Nodal Receptors==
 
  
  
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Developmental patterning signal.
 
Developmental patterning signal.
  
===Endoderm Development===
 
Endoderm differentiates to form the respiratory airway epithelium and glands. This epithelium is continuously replaced through life from a basal cell pool of undifferentiated airway progenitors. A recent study<ref name=PMID25564622><pubmed>25564622</pubmed></ref> has shown that the progenitor pool is regulated by the Notch3-Jagged signaling pathway. The mechanism appears dependent upon the availability of Jag1 and Jag2 (generating  parabasal cells) that later activates Notch1 and Notch2 leading to a secretory-multiciliated cell fate.
 
 
:'''L;inks:''' [[Respiratory System Development]]
 
 
===Mesoderm Development===
 
===Mesoderm Development===
  
===Cartilage Development===
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===StomachDevelopment===
 
 
 
 
===Hypothalamus Development===
 
  
 
:'''Links:''' [[Endocrine_-_Hypothalamus_Development|Hypothalamus Development]]
 
  
 
==Abnormalities==
 
==Abnormalities==
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{{External Links}}
 
{{External Links}}
  
* OMIM - [http://www.ncbi.nlm.nih.gov/omim/190198 NOTCH 1]
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* Online Mendelian Inheritance in Man (OMIM) [https://omim.org/entry/601265 NODAL] | [https://omim.org/entry/603037 LEFTY1]
 
 
  
  

Revision as of 08:25, 30 April 2017

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Introduction

Nodal together with Lefty are involved in the initial left-right (L-R) patterning of the axis of the embryo. This patterning signal is later used for many cell fate developmental processes.

Left-right (L-R) asymmetry include the position on the left side of the heart and spleen and the development of the curvature of the stomach.


Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular

Some Recent Findings

More recent papers  
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References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.

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Search term: Nodal

<pubmed limit=5>Nodal</pubmed>

Older papers  
These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.

See also the Discussion Page for other references listed by year and References on this current page.


Nodal Signaling

Nodal represents a family of transmembrane receptors passing only once through the plasma membrane.


Nodal Ligands

Functions

Developmental patterning signal.

Mesoderm Development

StomachDevelopment

Abnormalities

Links:

References

  1. <pubmed>27226324</pubmed>


Reviews

<pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed>

Search Pubmed

Search Bookshelf Nodal

Search Pubmed Now: Nodal Signaling

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.

  • Online Mendelian Inheritance in Man (OMIM) NODAL | LEFTY1


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Cite this page: Hill, M.A. (2021, January 24) Embryology Developmental Signals - Nodal. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Nodal

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© Dr Mark Hill 2021, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G