Developmental Signals - Nerve Growth Factor

Embryology - 19 Apr 2024        Expand to Translate
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Introduction

Rita Levi-Montalcini (1909 – 2012)

Nerve Growth Factor (NGF) was first discovered in the 1950's by Rita Levi-Montalcini with Stanley Cohen and Viktor Hamburger. See review Levi-Montalcini review 30 years later.

For which Rita Levi-Montalcini and Stanley Cohen received the 1986 Nobel Prize in Medicine.

The Nobel Prize in Physiology or Medicine 1986 - Stanley Cohen, Rita Levi-Montalcini "for their discoveries of growth factors"

Draft page - Notice removed when completed.

Historical: Cohen S. Levi-Montalcini R. and Hamburger V. A nerve growth-stimulating factor isolated from sarcomas 37 and 180. (1954) Proc Natl Acad Sci U S A. 40(10):1014-8. PMID: 16589582

Links: File:Rita Levi-Montalcini | Viktor Hamburger | Nobel Prize 1986 | Category:NGF

Some Recent Findings

Molecular evolution of vertebrate neurotrophins "Neurotrophins are a diverse class of structurally related proteins, essential for neuronal development, survival, plasticity and regeneration. They are characterized by major family members, such as the nerve growth factors (NGF), brain-derived neurotrophic factors (BDNF) and neurotrophin-3 (NT-3), which have been demonstrated here to lack coding sequence variations and follow the regime of negative selection, highlighting their extremely important conserved role in vertebrate homeostasis." Nerve growth factor: from the early discoveries to the potential clinical use "The physiological role of the neurotrophin nerve growth factor (NGF) has been characterized, since its discovery in the 1950s, first in the sensory and autonomic nervous system, then in central nervous, endocrine and immune systems. NGF plays its trophic role both during development and in adulthood, ensuring the maintenance of phenotypic and functional characteristic of several populations of neurons as well as immune cells."

More recent papers

This table allows an automated computer search of the external PubMed database using the listed "Search term" text link. This search now requires a manual link as the original PubMed extension has been disabled. The displayed list of references do not reflect any editorial selection of material based on content or relevance. References also appear on this list based upon the date of the actual page viewing. References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability. More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Nerve Growth Factor <pubmed limit=5>Nerve Growth Factor</pubmed>

Function

Neural

Links: Neural System Development

Signaling Pathway

Tyrosine Kinase Receptor A

TRKA

NTKR1 gene encodes the neurotrophic tyrosine kinase-1 receptor and belongs to a family of nerve growth factor receptors.

OMIM Links: TRKA

Nerve Growth Factor Receptor

NGFR; p75(NTR)

Receptor binds at low affinity NGF and other neurotrophins: brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NTF3), and neurotrophin-4 (NTF4).

OMIM Links: NGFR | BDNF | NTF3 | NTF4

Other Neural Growth Factors

• Brain-derived neurotrophic factor (BDNF)
• Glial cell line-derived neurotrophic factor (GDNF)
• Neurotrophic 3 (NT3)

OMIM

About OMIM "Online Mendelian Inheritance in Man OMIM is a comprehensive, authoritative, and timely compendium of human genes and genetic phenotypes. The full-text, referenced overviews in OMIM contain information on all known mendelian disorders and over 12,000 genes. OMIM focuses on the relationship between phenotype and genotype. It is updated daily, and the entries contain copious links to other genetics resources." OMIM

• NGF

References

Reviews

3323396 2828509

3301324 

Articles

All Rita Levi-Montalcini PMID references

<pubmed>22693607</pubmed>

Online Textbooks

• Molecular Biology of the Cell. 4th edition. Alberts B, Johnson A, Lewis J, et al.New York: Garland Science; 2002.
• Molecular Cell Biology. 4th edition. Lodish H, Berk A, Zipursky SL, et al.New York: W. H. Freeman; 2000.
• Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000.

Search PubMed

• Search PubMed: Nerve Growth Factor
• All Databases: Nerve Growth Factor

External Links

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• OMIM - NGF

Glossary Links

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Cite this page: Hill, M.A. (2024, April 19) Embryology Developmental Signals - Nerve Growth Factor. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Nerve_Growth_Factor

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G