Developmental Signals - Nanog
From Embryology
Notice - Mark Hill
Currently this page is only a template and will be updated (this notice removed when completed).
Introduction
| Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
- Phosphorylation stabilizes Nanog by promoting its interaction with Pin1[1]"Here we show that Nanog, a transcription factor crucial for the self-renewal of ESCs, is phosphorylated at multiple Ser/Thr-Pro motifs. This phosphorylation promotes the interaction between Nanog and the prolyl isomerase Pin1, leading to Nanog stabilization by suppressing its ubiquitination. Inhibition of Pin1 activity or disruption of Pin1-Nanog interaction in ESCs suppresses their capability to self-renew and to form teratomas in immunodeficient mice. Therefore, in addition to the stringent transcriptional regulation of Nanog, the expression level of Nanog is also modulated by posttranslational mechanisms."
Classification
Functions
Neural
Other
Signaling Pathway
References
- ↑ <pubmed>20622153</pubmed>
Search Pubmed
Search Bookshelf Nanog
July 2010 "Nanog"
Search Pubmed Now: Nanog
External Links
- UNSW Embryology - Molecular Notes
- OMIM - ??
Glossary Links
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Cite this page: Hill, M.A. (2024, April 23) Embryology Developmental Signals - Nanog. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Nanog
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
