Developmental Signals - Nanog

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Introduction

Human testis NANOG expression[1]
Shinya Yamanaka

NANOG plays a central role in regulating self-renewal in pluripotent stem cells and tumor cells. It is one of the 4 Yamanaka Factors, genes that can induce an adult cell to become a stem cell.


Stem Cell Links: Introduction | Timeline | Placental Cord Blood | Adult | Induced pluripotent stem cell | Yamanaka Factors | Somatic Cell Nuclear Transfer | Ethics | Organoids | Adult Human Cell Types | Category:Stem Cell


Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular

Some Recent Findings

  • Phosphorylation stabilizes Nanog by promoting its interaction with Pin1[2]"Here we show that Nanog, a transcription factor crucial for the self-renewal of ESCs, is phosphorylated at multiple Ser/Thr-Pro motifs. This phosphorylation promotes the interaction between Nanog and the prolyl isomerase Pin1, leading to Nanog stabilization by suppressing its ubiquitination. Inhibition of Pin1 activity or disruption of Pin1-Nanog interaction in ESCs suppresses their capability to self-renew and to form teratomas in immunodeficient mice. Therefore, in addition to the stringent transcriptional regulation of Nanog, the expression level of Nanog is also modulated by posttranslational mechanisms."
  • Nanog variability and pluripotency regulation of embryonic stem cells[3]"The expression of the transcription factors Oct4, Sox2, and Nanog is commonly associated with pluripotency of mouse embryonic stem (ES) cells. However, recent observations suggest that ES cell populations are heterogeneous with respect to the expression of Nanog and that individual ES cells reversibly change their Nanog expression level."

Classification

Functions

Required for embryonic stem cell self-renewal.

Spermatogenesis

The cartoons below show nanog expression in mouse and dog during spermatogenesis.[4]

Mouse- spermatozoa NANOG expression.jpg Each column represents the combination of different cell types that are present in seminiferous tubules at that specific stage.

Cell types that express NANOG are outlined in red and cell types that do not express NANOG have black and grey symbols.

Legend

  • 1–16 = steps in spermiogenesis
  • In = intermediate spermatogonia
  • B = type B spermatogonia
  • Pl = pre-leptotene stage
  • L = leptotene stage
  • Z = zygotene stage
  • P = pachytene stage
  • D = diplotene stage
  • 2nd = generation of secondary spermatocytes
  • Roman figures = stage of the epithelial cycle
Dog- spermatozoa NANOG expression.jpg

Signaling Pathway

Two-level process for the induction of stem cell differentiation[3]
Two-level process for the induction of stem cell differentiation[3]

References

  1. <pubmed>20539761</pubmed>
  2. <pubmed>20622153</pubmed>
  3. 3.0 3.1 3.2 <pubmed>20574542</pubmed>| PLoS One
  4. <pubmed>20539761</pubmed>| PLoS One.


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Cite this page: Hill, M.A. (2024, March 28) Embryology Developmental Signals - Nanog. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Nanog

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G