Developmental Signals - Nanog: Difference between revisions
From Embryology
m (moved Nanog to Developmental Signals - Nanog) |
|||
| Line 18: | Line 18: | ||
Required for embryonic stem cell self-renewal. | Required for embryonic stem cell self-renewal. | ||
===Spermatogenesis== | |||
The cartoons below show nanog expression in mouse and dog during spermatogenesis. | |||
[[File:Mouse- spermatozoa NANOG expression.jpg|600px]] | |||
[[File:Dog- spermatozoa NANOG expression.jpg|600px]] | |||
<ref><pubmed>20539761</pubmed>| [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0010987 PLoS One.]</ref> | |||
==Signaling Pathway== | ==Signaling Pathway== | ||
Revision as of 11:25, 19 November 2010
Notice - Mark Hill
Currently this page is only a template and will be updated (this notice removed when completed).
Introduction
Human testis NANOG expression[1]
| Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
- Phosphorylation stabilizes Nanog by promoting its interaction with Pin1[2]"Here we show that Nanog, a transcription factor crucial for the self-renewal of ESCs, is phosphorylated at multiple Ser/Thr-Pro motifs. This phosphorylation promotes the interaction between Nanog and the prolyl isomerase Pin1, leading to Nanog stabilization by suppressing its ubiquitination. Inhibition of Pin1 activity or disruption of Pin1-Nanog interaction in ESCs suppresses their capability to self-renew and to form teratomas in immunodeficient mice. Therefore, in addition to the stringent transcriptional regulation of Nanog, the expression level of Nanog is also modulated by posttranslational mechanisms."
- Nanog variability and pluripotency regulation of embryonic stem cells[3]"The expression of the transcription factors Oct4, Sox2, and Nanog is commonly associated with pluripotency of mouse embryonic stem (ES) cells. However, recent observations suggest that ES cell populations are heterogeneous with respect to the expression of Nanog and that individual ES cells reversibly change their Nanog expression level."
Classification
Functions
Required for embryonic stem cell self-renewal.
=Spermatogenesis
The cartoons below show nanog expression in mouse and dog during spermatogenesis.
Signaling Pathway
![Two-level process for the induction of stem cell differentiation[3]](/embryology/index.php?title=File:Stem_cell_nanog_model.png)
|
| Two-level process for the induction of stem cell differentiation[3] |
References
Search Pubmed
Search Bookshelf Nanog
July 2010 "Nanog" All (976) Review (77) Free Full Text (375)
Search Pubmed Now: Nanog
External Links
- UNSW Embryology - Molecular Notes
- Entrez Gene - NANOG Nanog homeobox - Homo sapiens
- OMIM - 607937 NANOG
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, April 20) Embryology Developmental Signals - Nanog. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Nanog
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
