Developmental Signals - Nanog: Difference between revisions
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Revision as of 16:14, 12 April 2017
Embryology - 19 Apr 2024 Expand to Translate |
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Introduction
NANOG plays a central role in regulating self-renewal in pluripotent stem cells and tumor cells.
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Nanog <pubmed limit=5>Nanog</pubmed> |
Classification
Functions
Required for embryonic stem cell self-renewal.
Blastocyst - Inner Cell Mass
In the early mouse embryo, Nano expression appears to be related to maintain of pluripotency in the blastocyst inner cell mass epiblast layer.[2]
Nanog expression pattern four phases:
- cleavage stages - very low levels
- morula stage - increased stochastically, no correlation with future cell fates.
- blastocyst stage (after 32-cell stage) - inner cell mass expression was up-regulated.
- blastocyst stage onwards - primitive endoderm repressed in an FGF signalling-dependent manner.
- Links: Morula | Blastocyst | Mouse Development | FGF
Spermatogenesis
The cartoons below show nanog expression in mouse and dog during spermatogenesis.[5]
Signaling Pathway
Two-level process for the induction of stem cell differentiation[4] |
References
Search Pubmed
Search Pubmed Now: Nanog
Search OMIM Nanog
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- Entrez Gene - NANOG Nanog homeobox - Homo sapiens
- OMIM - 607937 NANOG
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, April 19) Embryology Developmental Signals - Nanog. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Nanog
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G