Developmental Signals - Homeobox
The family of homeobox (Hox) proteins has been a focus of research for over 30 years. This family of genes were also the basis of the embryo patterning studies that led to the Nobel Prize in Medicine 1995. We now know that in addition to whole embryo axes patterning, this family of genes has many roles in establishing pattern throughout the embryo in different tissues and organs.
This signalling pathway has also been implicated in many developmental abnormalities and diseases.
|Fly wild-type head||Fly antennapedia head|
|Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular|
Some Recent Findings
|Proposed Hox protein classification|
Developmental patterning signal.
Hindbrain neural crest migration and Hox expression pattern
Adapted by permission from Macmillan Publishers Ltd: Nature Reviews Neuroscience (<pubmed>17948031</pubmed>), copyright (2007)
Vertebral element ossification between species.
- Links: Axial Skeleton Development
Mouse Limb Patterning Fgf and Hox Expression
Fgf and Hox expression in E10.5 to 10.75 wild-type embryonic forelimb autopod, compared to future E14.5 digit arrangement.
- Links: Limb Development
- <pubmed>20485555</pubmed>| PLoS One
- Yallowitz AR, Hrycaj SM, Short KM, Smyth IM, Wellik DM (2011) Hox10 Genes Function in Kidney Development in the Differentiation and Integration of the Cortical Stroma. PLoS ONE 6(8): e23410. PMID 21858105 PloS One
- <pubmed>20520839</pubmed>| PLoS One
- <pubmed>20540809</pubmed>| Reprod Biol Endocrinol.
- <pubmed>20956304</pubmed>| Proc Natl Acad Sci U S A.
- <pubmed>20386744</pubmed>| PMC2851570 | PLoS Genet.
<pubmed>20435029</pubmed> <pubmed>19651304</pubmed> <pubmed>15944185</pubmed> <pubmed>11604126</pubmed>
Search Bookshelf hox
July 2010 "hox" All (3509) Review (545) Free Full Text (1453)
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Cite this page: Hill, M.A. (2020, October 25) Embryology Developmental Signals - Homeobox. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Homeobox
- © Dr Mark Hill 2020, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G