Developmental Signals - Homeobox
Introduction
The family of homeobox (Hox) proteins has been a focus of research for over 30 years.
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
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Classification
Proposed Hox protein classification[2] |
Functions
Developmental patterning signal.
Neural
Hindbrain neural crest migration and Hox expression pattern[4]
A schematic diagram of a chick head at embryonic day two (Hamburger Hamilton Stages), showing pathways of neural crest migration in the chick and mouse embryo and patterns of Hox gene expression in the pharyngeal arches. Hox genes are expressed in neural crest cells, which emigrate predominantly from even-numbered rhombomeres into the pharyngeal (branchial) arches generating skeletal tissues and cranial ganglia.
Note that the first pharyngeal arch is free of Hox expression.
Legend
- PA - pharyngeal arch
- Md - mandibular part of pharyngeal arch 1
- Mx - maxillary part of pharyngeal arch 1
- OV - otic vesicle
- r - rhombomere
Adapted by permission from Macmillan Publishers Ltd: Nature Reviews Neuroscience (<pubmed>17948031</pubmed>), copyright (2007)
Other
Signaling Pathway
References
Search Bookshelf hox
Search Pubmed
July 2010 "hox" All (3509) Review (545) Free Full Text (1453)
Search Pubmed Now: Homeobox | hox
External Links
- UNSW Embryology - Molecular Notes | Musculoskeletal Notes
- OMIM - SONIC HEDGEHOG
Glossary Links
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Cite this page: Hill, M.A. (2024, March 29) Embryology Developmental Signals - Homeobox. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Homeobox
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G