Developmental Signals - Homeobox
Introduction
The family of homeobox (Hox) proteins has been a focus of research for over 30 years. This family of genes were also the basis of the embryo patterning studies that led to the Nobel Prize in Medicine 1995.
Fly wild-type head | Fly antennapedia head |
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
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Classification
Proposed Hox protein classification[3] |
Functions
Developmental patterning signal.
Neural
Hindbrain neural crest migration and Hox expression pattern[5]
Legend
Adapted by permission from Macmillan Publishers Ltd: Nature Reviews Neuroscience (<pubmed>17948031</pubmed>), copyright (2007) |
Limb
Mouse Limb Patterning Fgf and Hox Expression[6]
Fgf and Hox expression in E10.5 to 10.75 wild-type embryonic forelimb autopod, compared to future E14.5 digit arrangement.
Other
Signaling Pathway
References
- ↑ 1.0 1.1 <pubmed>20485555</pubmed>| PLoS One
- ↑ Yallowitz AR, Hrycaj SM, Short KM, Smyth IM, Wellik DM (2011) Hox10 Genes Function in Kidney Development in the Differentiation and Integration of the Cortical Stroma. PLoS ONE 6(8): e23410. PMID 21858105 PloS One
- ↑ 3.0 3.1 <pubmed>20520839</pubmed>| PLoS One
- ↑ <pubmed>20540809</pubmed>| Reprod Biol Endocrinol.
- ↑ <pubmed>17948031</pubmed>
- ↑ <pubmed>20386744</pubmed>| PMC2851570 | PLoS Genet.
Reviews
<pubmed>20435029</pubmed> <pubmed>19651304</pubmed> <pubmed>11604126</pubmed>
Articles
Search Pubmed
Search Bookshelf hox
July 2010 "hox" All (3509) Review (545) Free Full Text (1453)
Search Pubmed Now: Homeobox | hox
External Links
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- Nobel Prize - Medicine 1995
- OMIM - SONIC HEDGEHOG
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Cite this page: Hill, M.A. (2024, April 24) Embryology Developmental Signals - Homeobox. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Homeobox
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G