Developmental Signals - Homeobox: Difference between revisions
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* '''Hox10 Genes Function in Kidney Development in the Differentiation and Integration of the Cortical Stroma''' <ref>Yallowitz AR, Hrycaj SM, Short KM, Smyth IM, Wellik DM (2011) Hox10 Genes Function in Kidney Development in the Differentiation and Integration of the Cortical Stroma. PLoS ONE 6(8): e23410. [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0023410 PloS One]</ref> "Consistent with loss of cortical stromal cell function, Hox10 mutant kidneys display reduced and aberrant ureter branching, decreased nephrogenesis. These data therefore provide critical novel insights into the cellular and genetic mechanisms governing cortical cell development during kidney organogenesis. These results, combined with previous evidence demonstrating that Hox11 genes are necessary for patterning the metanephric mesenchyme, support a model whereby distinct populations in the nephrogenic cord are regulated by unique Hox codes, and that differential Hox function along the AP axis of the nephrogenic cord is critical for the differentiation and integration of these cell types during kidney organogenesis." | |||
* '''Proposed Hox protein classification'''<ref name="PMID20520839"><pubmed>20520839</pubmed>| [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0010820 PLoS One]</ref>"Our classification scheme offers a higher-resolution classification that is in accordance with phylogenetic as well as experimental data and, thereby, provides a novel basis for experiments, such as comparative and functional analyses of Hox-proteins." | * '''Proposed Hox protein classification'''<ref name="PMID20520839"><pubmed>20520839</pubmed>| [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0010820 PLoS One]</ref>"Our classification scheme offers a higher-resolution classification that is in accordance with phylogenetic as well as experimental data and, thereby, provides a novel basis for experiments, such as comparative and functional analyses of Hox-proteins." | ||
* '''Homeobox A7 up-regulation of epidermal growth factor receptor expression in human granulosa cells'''<ref name="PMID20540809"><pubmed>20540809</pubmed>| [http://www.rbej.com/content/8/1/61 Reprod Biol Endocrinol.]</ref>"Our present study reveals a novel mechanistic role for HOXA7 in modulating granulosa cell proliferation via the regulation of EGFR. This finding contributes to the knowledge of the pro-proliferation effect of HOXA7 in granulosa cell growth and differentiation." | * '''Homeobox A7 up-regulation of epidermal growth factor receptor expression in human granulosa cells'''<ref name="PMID20540809"><pubmed>20540809</pubmed>| [http://www.rbej.com/content/8/1/61 Reprod Biol Endocrinol.]</ref>"Our present study reveals a novel mechanistic role for HOXA7 in modulating granulosa cell proliferation via the regulation of EGFR. This finding contributes to the knowledge of the pro-proliferation effect of HOXA7 in granulosa cell growth and differentiation." |
Revision as of 11:39, 2 September 2011
Introduction
The family of homeobox (Hox) proteins has been a focus of research for over 30 years.
Fly wild-type head | Fly antennapedia head |
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
|
Classification
Proposed Hox protein classification[3] |
Functions
Developmental patterning signal.
Neural
Hindbrain neural crest migration and Hox expression pattern[5]
Legend
Adapted by permission from Macmillan Publishers Ltd: Nature Reviews Neuroscience (<pubmed>17948031</pubmed>), copyright (2007) |
Other
Signaling Pathway
References
- ↑ 1.0 1.1 <pubmed>20485555</pubmed>| PLoS One
- ↑ Yallowitz AR, Hrycaj SM, Short KM, Smyth IM, Wellik DM (2011) Hox10 Genes Function in Kidney Development in the Differentiation and Integration of the Cortical Stroma. PLoS ONE 6(8): e23410. PloS One
- ↑ 3.0 3.1 <pubmed>20520839</pubmed>| PLoS One
- ↑ <pubmed>20540809</pubmed>| Reprod Biol Endocrinol.
- ↑ <pubmed>17948031</pubmed>
Reviews
<pubmed>20435029</pubmed> <pubmed>19651304</pubmed> <pubmed>11604126</pubmed>
Articles
Search Pubmed
Search Bookshelf hox
July 2010 "hox" All (3509) Review (545) Free Full Text (1453)
Search Pubmed Now: Homeobox | hox
External Links
- UNSW Embryology - Molecular Notes | Musculoskeletal Notes
- OMIM - SONIC HEDGEHOG
Glossary Links
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Cite this page: Hill, M.A. (2024, April 23) Embryology Developmental Signals - Homeobox. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Homeobox
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G