Developmental Signals - Homeobox: Difference between revisions
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Mouse Limb Patterning Fgf and Hox Expression<ref><pubmed>20386744</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851570 PMC2851570] | [http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000901 PLoS Genet.]</ref> | Mouse Limb Patterning Fgf and Hox Expression<ref><pubmed>20386744</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851570 PMC2851570] | [http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000901 PLoS Genet.]</ref> | ||
Fgf and Hox expression in E10.5 to 10.75 wild-type embryonic forelimb autopod, compared to future E14.5 digit arrangement. | Fgf and Hox expression in [[:Category:Mouse E10.5|E10.5]] to 10.75 wild-type embryonic forelimb autopod, compared to future [[:Category:Mouse E14.5|E14.5]] digit arrangement. | ||
[[File:Hoxa gene expression in limb bud 01.jpg|600px]] | [[File:Hoxa gene expression in limb bud 01.jpg|600px]] | ||
Expression of Hoxa4, Hoxa9, Hoxa10, Hoxa11, Hoxa11 antisense (Hoxa11as), and Hoxa13 in E12.5 limb buds.<ref><pubmed>24465181</pubmed>| [http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001773 PLoS Biol.]</ref> | Expression of Hoxa4, Hoxa9, Hoxa10, Hoxa11, Hoxa11 antisense (Hoxa11as), and Hoxa13 in [[:Category:Mouse E12.5|E12.5]] limb buds.<ref><pubmed>24465181</pubmed>| [http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001773 PLoS Biol.]</ref> | ||
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File:Ascidian hox expression 01.jpg|Ascidian hox expression | File:Ascidian hox expression 01.jpg|Ascidian hox expression | ||
File:Mouse_E8.5-E10.5_Hoxa3.jpg|Hoxa3 Mouse E8.5-E10.5 | File:Mouse_E8.5-E10.5_Hoxa3.jpg|Hoxa3 Mouse E8.5-E10.5 | ||
File:Mouse_E8.5_Hoxa3.jpg|Hoxa3 Mouse E8.5 | File:Mouse_E8.5_Hoxa3.jpg|Hoxa3 [[:Category:Mouse E8.5|Mouse E8.5]] | ||
File:Mouse_E9.5_Hoxa3.jpg|Hoxa3 Mouse E9.5 | File:Mouse_E9.5_Hoxa3.jpg|Hoxa3 [[:Category:Mouse E9.5|Mouse E9.5]] | ||
File:Mouse_E10.5_Hoxa3.jpg|Hoxa3 Mouse E10.5 | File:Mouse_E10.5_Hoxa3.jpg|Hoxa3 [[:Category:Mouse E10.5|Mouse E10.5]] | ||
File:Mouse_Hoxb5.jpg|Hoxb5 Mouse | File:Mouse_Hoxb5.jpg|Hoxb5 Mouse | ||
File:Mouse_Hoxb6.jpg|Hoxb6 Mouse | File:Mouse_Hoxb6.jpg|Hoxb6 Mouse |
Revision as of 21:09, 29 January 2015
Embryology - 18 Apr 2024 Expand to Translate |
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Introduction
The family of homeobox (Hox) proteins has been a focus of research for over 30 years. This family of genes were also the basis of the embryo patterning studies that led to the Nobel Prize in Medicine 1995. We now know that in addition to whole embryo axes patterning, this family of genes has many roles in establishing pattern throughout the embryo in different tissues and organs.
This signalling pathway has also been implicated in many developmental abnormalities and diseases.
Fly wild-type head | Fly antennapedia head |
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Hox <pubmed limit=5>Hox</pubmed> |
Classification
Proposed Hox protein classification[6] |
Human Hox
Chromosomal Distribution of Human Homeobox Genes[8]
Functions
Developmental patterning signal.
Neural
Hindbrain neural crest migration and Hox expression pattern[9]
Legend
Adapted by permission from Macmillan Publishers Ltd: Nature Reviews Neuroscience (<pubmed>17948031</pubmed>), copyright (2007) |
Axial Skeleton
Vertebral element ossification between species.[10]
- Links: Axial Skeleton Development
Limb
Mouse Limb Patterning Fgf and Hox Expression[11]
Fgf and Hox expression in E10.5 to 10.75 wild-type embryonic forelimb autopod, compared to future E14.5 digit arrangement.
Expression of Hoxa4, Hoxa9, Hoxa10, Hoxa11, Hoxa11 antisense (Hoxa11as), and Hoxa13 in E12.5 limb buds.[12]
- Links: Limb Development
Other
Signaling Pathway
Additional Images
Hoxa3 Mouse E8.5
Hoxa3 Mouse E9.5
Hoxa3 Mouse E10.5
References
- ↑ 1.0 1.1 <pubmed>20485555</pubmed>| PLoS One
- ↑ <pubmed>25219855</pubmed>
- ↑ <pubmed>24449840</pubmed>
- ↑ <pubmed>22085760</pubmed>
- ↑ Yallowitz AR, Hrycaj SM, Short KM, Smyth IM, Wellik DM (2011) Hox10 Genes Function in Kidney Development in the Differentiation and Integration of the Cortical Stroma. PLoS ONE 6(8): e23410. PMID 21858105 PloS One
- ↑ 6.0 6.1 <pubmed>20520839</pubmed>| PLoS One
- ↑ <pubmed>20540809</pubmed>| Reprod Biol Endocrinol.
- ↑ <pubmed>17963489</pubmed>| BMC Biol.
- ↑ <pubmed>17948031</pubmed>
- ↑ <pubmed>20956304</pubmed>| Proc Natl Acad Sci U S A.
- ↑ <pubmed>20386744</pubmed>| PMC2851570 | PLoS Genet.
- ↑ <pubmed>24465181</pubmed>| PLoS Biol.
Reviews
<pubmed>20435029</pubmed> <pubmed>19651304</pubmed> <pubmed>15944185</pubmed> <pubmed>11604126</pubmed>
Articles
Search Pubmed
Search Bookshelf hox
July 2010 "hox" All (3509) Review (545) Free Full Text (1453)
Search Pubmed Now: Hox Homeobox
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- Nobel Prize - Medicine 1995
- OMIM - SONIC HEDGEHOG
Glossary Links
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Cite this page: Hill, M.A. (2024, April 18) Embryology Developmental Signals - Homeobox. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Homeobox
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G