Developmental Signals - Homeobox: Difference between revisions
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* '''Hoxa5 transcriptional complexity in the mouse embryo'''<ref name="PMID20485555" />Our observation that the Hoxa5 larger transcripts possess a developmentally-regulated expression combined to the increasing sum of data on the role of long noncoding RNAs in transcriptional regulation suggest that the Hoxa5 larger transcripts may participate in the control of Hox gene expression. | * '''Hoxa5 transcriptional complexity in the mouse embryo'''<ref name="PMID20485555" />Our observation that the Hoxa5 larger transcripts possess a developmentally-regulated expression combined to the increasing sum of data on the role of long noncoding RNAs in transcriptional regulation suggest that the Hoxa5 larger transcripts may participate in the control of Hox gene expression. | ||
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! More recent papers | ! More recent papers | ||
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| Proposed Hox protein classification<ref name="PMID20520839" /> | | Proposed Hox protein classification<ref name="PMID20520839" /> | ||
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==Human Hox== | |||
[[File:Human homeobox genes.jpg|alt=Ideograms Human homeobox genes|800px]] | |||
Chromosomal Distribution of Human Homeobox Genes<ref name=PMID17963489><pubmed>17963489</pubmed>| [http://www.biomedcentral.com/1741-7007/5/47 BMC Biol.]</ref> | |||
==Functions== | ==Functions== | ||
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<gallery> | <gallery> | ||
File:Hox deuterostomes phylogenetic tree.jpg|Hox deuterostomes phylogenetic tree PMID 23819519 | File:Hox deuterostomes phylogenetic tree.jpg|Hox deuterostomes phylogenetic tree PMID 23819519 | ||
File:Mouse_E8.5-E10.5_Hoxa3.jpg|Mouse E8.5-E10.5 | |||
File:Mouse_E8.5_Hoxa3.jpg|Mouse E8.5 | |||
File:Mouse_E9.5_Hoxa3.jpg|Mouse E9.5 | |||
File:Mouse_E10.5_Hoxa3.jpg|Mouse E10.5 | |||
</gallery> | </gallery> | ||
==References== | ==References== | ||
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==External Links== | ==External Links== | ||
{{External Links}} | {{External Links}} | ||
Revision as of 22:32, 9 July 2014
Embryology - 24 Apr 2024 Expand to Translate |
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Introduction
The family of homeobox (Hox) proteins has been a focus of research for over 30 years. This family of genes were also the basis of the embryo patterning studies that led to the Nobel Prize in Medicine 1995. We now know that in addition to whole embryo axes patterning, this family of genes has many roles in establishing pattern throughout the embryo in different tissues and organs.
This signalling pathway has also been implicated in many developmental abnormalities and diseases.
Fly wild-type head | Fly antennapedia head |
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Hox <pubmed limit=5>Hox</pubmed> |
Classification
Proposed Hox protein classification[5] |
Human Hox
Chromosomal Distribution of Human Homeobox Genes[7]
Functions
Developmental patterning signal.
Neural
Hindbrain neural crest migration and Hox expression pattern[8]
Legend
Adapted by permission from Macmillan Publishers Ltd: Nature Reviews Neuroscience (<pubmed>17948031</pubmed>), copyright (2007) |
Axial Skeleton
Vertebral element ossification between species.[9]
- Links: Axial Skeleton Development
Limb
Mouse Limb Patterning Fgf and Hox Expression[10]
Fgf and Hox expression in E10.5 to 10.75 wild-type embryonic forelimb autopod, compared to future E14.5 digit arrangement.
- Links: Limb Development
Other
Signaling Pathway
Additional Images
References
- ↑ 1.0 1.1 <pubmed>20485555</pubmed>| PLoS One
- ↑ <pubmed>24449840</pubmed>
- ↑ <pubmed>22085760</pubmed>
- ↑ Yallowitz AR, Hrycaj SM, Short KM, Smyth IM, Wellik DM (2011) Hox10 Genes Function in Kidney Development in the Differentiation and Integration of the Cortical Stroma. PLoS ONE 6(8): e23410. PMID 21858105 PloS One
- ↑ 5.0 5.1 <pubmed>20520839</pubmed>| PLoS One
- ↑ <pubmed>20540809</pubmed>| Reprod Biol Endocrinol.
- ↑ <pubmed>17963489</pubmed>| BMC Biol.
- ↑ <pubmed>17948031</pubmed>
- ↑ <pubmed>20956304</pubmed>| Proc Natl Acad Sci U S A.
- ↑ <pubmed>20386744</pubmed>| PMC2851570 | PLoS Genet.
Reviews
<pubmed>20435029</pubmed> <pubmed>19651304</pubmed> <pubmed>15944185</pubmed> <pubmed>11604126</pubmed>
Articles
Search Pubmed
Search Bookshelf hox
July 2010 "hox" All (3509) Review (545) Free Full Text (1453)
Search Pubmed Now: Hox Homeobox
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- Nobel Prize - Medicine 1995
- OMIM - SONIC HEDGEHOG
Glossary Links
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Cite this page: Hill, M.A. (2024, April 24) Embryology Developmental Signals - Homeobox. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Homeobox
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G