Developmental Signals - Hippo: Difference between revisions
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Revision as of 19:03, 19 March 2018
Embryology - 24 Apr 2024 Expand to Translate |
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Introduction
The Hippo (Hpo) pathway, first identified in Drosophila, controls organ size by regulating cell proliferation (inhibition) and apoptosis (induction). In contrast, the TOR signalling pathway regulates organ size by stimulating cell growth, thus increasing cell size.
Hippo is a protein kinase cascade pathway, getting its name from the “hippopotamus”-like fly phenotype.
Fly Phenotype (dorsal view head thorax SEM) | |
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Hippo-type (hpo) | Wild-type (WT) |
Image source[1] |
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Embryo Hippo | Images <pubmed limit=5>Embryo Hippo</pubmed> |
Early Development
Zygote
Maternally inherited Yes-associated protein (Yap), a co-activator of TEAD family transcription factors, plays a key role in activating embryonic transcription following fertilization in the mouse. Lysophosphatidic acid (LPA) in the mouse tubal fluid binds to its G-protein coupled receptor at the plasma membrane, and induces the activation of YAP by inhibiting LATS1/2. [2]
- Links: Zygote | Mouse Development
Blastocyst
Mouse blastocyst (32 cell stage) | |
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phosphorylation of angiomotin at adherens junctions | cell polarization sequesters Amot from basolateral adherens junctions |
active Hippo signaling | inactive Hippo signaling |
inner cells | outer cells |
inner cell mass (ICM) fate | trophectoderm (TE) fate |
- (Table data see review[3] Notch signaling also has a role in blastocyst fate development)
- Links: Blastocyst
Bone
Hippo signaling pathway has recently been identified as a key regulator of osteoclast formation, see review.[5]
- Hippo signaling pathway regulatory molecules - RASSF2, NF2, MST1/2, SAV1, LATS1/2, MOB1, YAP, and TAZ.
- osteoclast differentiation - upon activation, MST and LAST, transcriptional co-activators YAP and TAZ bind to the members of the TEA domain (TEAD) family transcription factors
- regulate expression of downstream target genes connective tissue growth factor (CTGF/CCN2) and cysteine-rich protein 61 (CYR61/CCN1).
- RANKL-mediated signaling cascades including NF-κB, MAPKs, AP1, and NFATc1, Hippo-signaling molecules such as YAP/TAZ/TEAD complex, RASSF2, MST2, and Ajuba could also potentially modulate osteoclast differentiation and function.
- Links: Bone Development
References
- ↑ 1.0 1.1 <pubmed>24336504</pubmed>| Nat Rev Drug Discov.
- ↑ 2.0 2.1 <pubmed>26902285</pubmed>
- ↑ 3.0 3.1 <pubmed>25986053</pubmed>
- ↑ <pubmed>25778702</pubmed>
- ↑ Yang W, Han W, Qin A, Wang Z, Xu J & Qian Y. (2018). The emerging role of Hippo signaling pathway in regulating osteoclast formation. J. Cell. Physiol. , 233, 4606-4617. PMID: 29219182 DOI.
Reviews
<pubmed></pubmed> <pubmed></pubmed> <pubmed>26032720</pubmed> <pubmed>22575479</pubmed> <pubmed>21808241</pubmed> <pubmed>19517570</pubmed>
Articles
<pubmed></pubmed> <pubmed></pubmed> <pubmed>26416966</pubmed> <pubmed>25628125</pubmed> <pubmed>25918243</pubmed>
Search Pubmed
Search Bookshelf Hippo
Search Pubmed Now: Hippo
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, April 24) Embryology Developmental Signals - Hippo. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Hippo
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G