Developmental Signals - Hippo: Difference between revisions

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Embryology - 19 Apr 2024 Expand to Translate
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Introduction

The Hippo pathway, first identified in Drosophila, controls organ size by regulating cell proliferation and apoptosis.

Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular

| Category:Hippo

Some Recent Findings

Retinoic acid signaling and neuronal differentiation^[1] "The identification of neurological symptoms caused by vitamin A deficiency pointed to a critical, early developmental role of vitamin A and its metabolite, retinoic acid (RA). The ability of RA to induce post-mitotic, neural phenotypes in various stem cells, in vitro, served as early evidence that RA is involved in the switch between proliferation and differentiation. In vivo studies have expanded this "opposing signal" model, and the number of primary neurons an embryo develops is now known to depend critically on the levels and spatial distribution of RA. The proneural and neurogenic transcription factors that control the exit of neural progenitors from the cell cycle and allow primary neurons to develop are partly elucidated, but the downstream effectors of RA receptor (RAR) signaling (many of which are putative cell cycle regulators) remain largely unidentified. The molecular mechanisms underlying RA-induced primary neurogenesis in anamniote embryos are starting to be revealed; however, these data have been not been extended to amniote embryos. There is growing evidence that bona fide RARs are found in some mollusks and other invertebrates, but little is known about their necessity or functions in neurogenesis. One normal function of RA is to regulate the cell cycle to halt proliferation, and loss of RA signaling is associated with dedifferentiation and the development of cancer. Identifying the genes and pathways that mediate cell cycle exit downstream of RA will be critical for our understanding of how to target tumor differentiation. Overall, elucidating the molecular details of RAR-regulated neurogenesis will be decisive for developing and understanding neural proliferation-differentiation switches throughout development."

More recent papers
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link. This search now requires a manual link as the original PubMed extension has been disabled. The displayed list of references do not reflect any editorial selection of material based on content or relevance. References also appear on this list based upon the date of the actual page viewing. References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability. More? References \| Discussion Page \| Journal Searches \| 2019 References \| 2020 References Search term: Embryo Hippo \| Images <pubmed limit=5>Embryo Hippo</pubmed>

Organ Expression

Endoderm

Fetal Gonad

Neural

References

↑ <pubmed>25558812</pubmed>

Reviews

Articles

Search Pubmed

Search Bookshelf Hippo

Search Pubmed Now: Hippo

Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Cite this page: Hill, M.A. (2024, April 19) Embryology Developmental Signals - Hippo. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Hippo

What Links Here?

[PMID25558812-1] <pubmed>25558812</pubmed>

[1]

@@ Line 4: / Line 4: @@
-{{Factor Links}}| [[:Category:Retinoic acid|Category:Retinoic acid]]
+{{Factor Links}}| [[:Category:Hippo|Category:Hippo]]
 ==Some Recent Findings==
@@ Line 17: / Line 17: @@
 | [[File:Mark_Hill.jpg|90px|left]] {{Most_Recent_Refs}}
-Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Embryo+Retinoic+acid ''Embryo Retinoic acid''] | [http://www.ncbi.nlm.nih.gov/pmc/?term=Retinoic+acid&report=imagesdocsum ''Images'']
+Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Embryo+Hippo ''Embryo Hippo''] | [http://www.ncbi.nlm.nih.gov/pmc/?term=Hippo&report=imagesdocsum ''Images'']
-<pubmed limit=5>Embryo Retinoic acid</pubmed>
+<pubmed limit=5>Embryo Hippo</pubmed>
 |}
 ==Organ Expression==
-[[File:Rar gene expression.jpg]]
-Summary of Rar gene expression patterns in mouse developing organ systems.<ref><pubmed>19471585</pubmed></ref>
 ==Endoderm==
-[[File:Chicken_antero-posterior_endoderm_patterning_01.jpg|alt=Chicken antero-posterior endoderm patterning cartoon|400px]]
-Chicken antero-posterior endoderm patterning<ref name=PMID19516907<pubmed>19516907</pubmed>| [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0005845 PLoS One.]</ref>
-:'''Links:''' [[Endoderm]] | [[Chicken Development]]
 ==Fetal Gonad==
-[[File:Human fetal gonad retinoid receptor expression.jpg|600px]]
-Immunohistochemical localisation of retinoid receptor expression in the human fetal gonad<ref>Childs AJ, Cowan G, Kinnell HL, Anderson RA, Saunders PTK (2011) '''Retinoic Acid Signalling and the Control of Meiotic Entry in the Human Fetal Gonad.''' PLoS ONE 6(6): e20249. [http://www.ncbi.nlm.nih.gov/pubmed/21674038 PMID 21674038] | [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0020249 PLoS One]</ref>
 ==Neural==
-[[File:Model retinoic acid extracellular signal-regulated kinase and Wnt pathway interactions.jpg|600px]]
-Model retinoic acid extracellular signal-regulated kinase and Wnt pathway interactions<ref><pubmed>19642999</pubmed></ref>
-[[File:Mouse_embryo_cortex_radial_expansion.jpg|600px]]
-RA Is Not Required for Radial Expansion of the Embryonic Cortex
 ==References==
 <references/>
+===Reviews===
+<pubmed></pubmed>
+<pubmed></pubmed>
 ===Articles===
-<pubmed>21673209</pubmed>| [http://www.cfp.ca/content/57/6/665.long Can Fam Physician]
+<pubmed></pubmed>
+<pubmed></pubmed>
 ===Search Pubmed===
-'''Search Bookshelf''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=Books&cmd=search&term=Retinoic%20acid Retinoic acid]
+'''Search Bookshelf''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=Books&cmd=search&term=Hippo Hippo]
-'''Search Pubmed Now:''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=Retinoic%20acid Retinoic acid]
+'''Search Pubmed Now:''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=Hippo Hippo]
@@ Line 73: / Line 59: @@
 [[Category:Molecular]] [[Category:Pattern]]
-[[Category:Neural]] [[Category:Limb]]
 [[Category:Hippo]]