Difference between revisions of "Developmental Mechanism - Tube Formation"

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Introduction

Throughout the body are many structures which are described as "tubular", that is they have a cellular wall with a hollow and generally fluid-filled core.

How do you make a "pipe" from cells, are there common mechanisms of this tube formation or a number of different ways of generating hollow structures? In research there does not seem to be a "tube research group", but a number of embryology and cell biology research laboratories are now looking at how cellular tubes form in their particular tissue of interest (heart, blood vessels, neural, gastrointestinal tract, respiratory tract, kidney, genital).


Mechanism - "a process, technique, or system for achieving a result".


Mechanism Links: mitosis | cell migration | cell junctions |epithelial invagination | epithelial mesenchymal transition | mesenchymal epithelial transition | epithelial mesenchymal interaction | morphodynamics | tube formation | apoptosis | autophagy | axes formation | time | molecular

Some Recent Findings

  • Fusion of airways during avian lung development constitutes a novel mechanism for the formation of continuous lumena in multicellular epithelia[1] "During development of the avian lung, the initially terminally branched epithelial tree later forms a continuous network of airways. This occurs via a large-scale epithelial fusion event, wherein airways that originate proximally collide with those that originate distally to form one continuous lumen. Here, we found that prior to fusion, the epithelium of the embryonic chicken lung undergoes a shape change to permit the initiation and extension of new branches which contain the cells that initiate contact. These changes in epithelial shape coincide with the differentiation of smooth muscle cells that wrap the airways. From these nascent epithelial branches, individual cells form cytoskeletal protrusions that extend toward and form a bridge with their target airway. Additional cells then join the fusion site, forming a bilayered epithelium. During this process, the basement membrane around the prefusion epithelium degrades and then reforms after fusion. The epithelial bilayer then undergoes apoptosis, clearing the path between the two lumens. The process of airway epithelial fusion in the developing chicken lung constitutes a novel mechanism for the generation of complex multicellular tubes and suggests a conserved role for smooth muscle in the shaping of airway epithelia." chicken | lung
  • Review - Insane in the apical membrane: Trafficking events mediating apicobasal epithelial polarity during tube morphogenesis[2] "The creation of cellular tubes is one of the most vital developmental processes, resulting in the formation of most organ types. Cells have co-opted a number of different mechanisms for tube morphogenesis that vary among tissues and organisms; however, generation and maintenance of cell polarity is fundamental for successful lumenogenesis. Polarized membrane transport has emerged as a key driver not only for establishing individual epithelial cell polarity, but also for coordination of epithelial polarization during apical lumen formation and tissue morphogenesis. In recent years, much work has been dedicated to identifying membrane trafficking regulators required for lumenogenesis."
More recent papers  
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Search term: Developmental Tube Formation

Older papers  
These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.

See also the Discussion Page for other references listed by year and References on this current page.

  • Effects of nanostructures and mouse embryonic stem cells on in vitro morphogenesis of rat testicular cords[3] "Morphogenesis of tubular structures is a common event during embryonic development. The signals providing cells with topographical cues to define a cord axis and to form new compartments surrounded by a basement membrane are poorly understood. Male gonadal differentiation is a late event during organogenesis and continues into postnatal life. The cellular changes resemble the mechanisms during embryonic life leading to tubular structures in other organs. ...Our studies show that epithelial (Sertoli cell) and mesenchymal (peritubular cells) cells crosstalk and orchestrate the formation of cords in response to physical features of the underlying matrix as well as secretory factors from ES cells." testis
  • MIM regulates vertebrate neural tube closure[4] "Neural tube closure is a critical morphogenetic event that is regulated by dynamic changes in cell shape and behavior. Although previous studies have uncovered a central role for the non-canonical Wnt signaling pathway in neural tube closure, the underlying mechanism remains poorly resolved. Here, we show that the missing in metastasis (MIM; Mtss1) protein, previously identified as a Hedgehog response gene and actin and membrane remodeling protein, specifically binds to Daam1 and couples non-canonical Wnt signaling to neural tube closure."
  • Apical constriction: a cell shape change that can drive morphogenesis[5] "Biologists have long recognized that dramatic bending of a cell sheet may be driven by even modest shrinking of the apical sides of cells. Cell shape changes and tissue movements like these are at the core of many of the morphogenetic movements that shape animal form during development, driving processes such as gastrulation, tube formation, and neurulation. The mechanisms of such cell shape changes must integrate developmental patterning information in order to spatially and temporally control force production-issues that touch on fundamental aspects of both cell and developmental biology and on birth defects research. How does developmental patterning regulate force-producing mechanisms, and what roles do such mechanisms play in development? Work on apical constriction from multiple systems including Drosophila, Caenorhabditis elegans, sea urchin, Xenopus, chick, and mouse has begun to illuminate these issues. Here, we review this effort to explore the diversity of mechanisms of apical constriction, the diversity of roles that apical constriction plays in development, and the common themes that emerge from comparing systems."

References

  1. Palmer MA & Nelson CM. (2020). Fusion of airways during avian lung development constitutes a novel mechanism for the formation of continuous lumena in multicellular epithelia. Dev. Dyn. , , . PMID: 32510705 DOI.
  2. Jewett CE & Prekeris R. (2018). Insane in the apical membrane: Trafficking events mediating apicobasal epithelial polarity during tube morphogenesis. Traffic , , . PMID: 29766620 DOI.
  3. Pan F, Chi L & Schlatt S. (2013). Effects of nanostructures and mouse embryonic stem cells on in vitro morphogenesis of rat testicular cords. PLoS ONE , 8, e60054. PMID: 23555881 DOI.
  4. Liu W, Komiya Y, Mezzacappa C, Khadka DK, Runnels L & Habas R. (2011). MIM regulates vertebrate neural tube closure. Development , 138, 2035-47. PMID: 21471152 DOI.
  5. Sawyer JM, Harrell JR, Shemer G, Sullivan-Brown J, Roh-Johnson M & Goldstein B. (2010). Apical constriction: a cell shape change that can drive morphogenesis. Dev. Biol. , 341, 5-19. PMID: 19751720 DOI.


Textbooks

Reviews

Berg CA. (2008). Tube formation in Drosophila egg chambers. Tissue Eng Part A , 14, 1479-88. PMID: 18707228 DOI.

Articles

Narboux-Neme N, Ekker M, Levi G & Heude E. (2019). Posterior axis formation requires Dlx5/Dlx6 expression at the neural plate border. PLoS ONE , 14, e0214063. PMID: 30889190 DOI.

Blanchard G. (2018). A 3D cell shape that enables tube formation. Nature , 561, 182-183. PMID: 30202053 DOI.

Basak S, Vilasagaram S, Naidu K & Duttaroy AK. (2019). Insulin-dependent, glucose transporter 1 mediated glucose uptake and tube formation in the human placental first trimester trophoblast cells. Mol. Cell. Biochem. , 451, 91-106. PMID: 30003444 DOI.


Search PubMed

Search Pubmed: developmental tube formation

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Mechanism Links: mitosis | cell migration | cell junctions |epithelial invagination | epithelial mesenchymal transition | mesenchymal epithelial transition | epithelial mesenchymal interaction | morphodynamics | tube formation | apoptosis | autophagy | axes formation | time | molecular


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Cite this page: Hill, M.A. (2020, October 27) Embryology Developmental Mechanism - Tube Formation. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Mechanism_-_Tube_Formation

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© Dr Mark Hill 2020, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G