Developmental Mechanism - Morphodynamics: Difference between revisions
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* '''Sticking, steering, squeezing and shearing: cell movements driven by heterotypic mechanical forces'''{{#pmid:29719271|PMID29719271}} "During development, the immune response and cancer, cells of different types interact mechanically. Here we review how such heterotypic mechanical interactions enable cell movements. We begin by analyzing the heterotypic forces that single cells use to adhere and squeeze through tight barriers, as in the case of leucocyte extravasation and cancer metastasis. We next focus on the different mechanisms by which adjacent tissues influence each other's movements, with particular emphasis on dragging forces during dorsal closure in Drosophila and shearing forces during gastrulation in zebrafish. Finally, we discuss the mechanotransduction feedback loops that enable different cell types to steer each other's migration during development and cancer. We illustrate these migration modes focusing on the combination of attractive and repulsive cues during co-migration of neural crest cells and placodes in Xenopus, and of fibroblasts and cancer cells during invasion. Throughout the review, we discuss the nature of the heterotypic contact, which may involve both homophilic and heterophilic interactions between adhesion receptors." | |||
* '''Review - Tissue morphodynamics shaping the early mouse embryo'''{{#pmid:26820524|PMID26820524}} "Generation of the elongated vertebrate body plan from the initially radially symmetrical embryo requires comprehensive changes to tissue form. These shape changes are generated by specific underlying cell behaviors, coordinated in time and space. Major principles and also specifics are emerging, from studies in many model systems, of the cell and physical biology of how region-specific cell behaviors produce regional tissue morphogenesis, and how these, in turn, are integrated at the level of the embryo. New technical approaches have made it possible more recently, to examine the morphogenesis of the mouse embryo in depth, and to elucidate the underlying cellular mechanisms. This review focuses on recent advances in understanding the cellular basis for the early fundamental events that establish the basic form of the embryo." | * '''Review - Tissue morphodynamics shaping the early mouse embryo'''{{#pmid:26820524|PMID26820524}} "Generation of the elongated vertebrate body plan from the initially radially symmetrical embryo requires comprehensive changes to tissue form. These shape changes are generated by specific underlying cell behaviors, coordinated in time and space. Major principles and also specifics are emerging, from studies in many model systems, of the cell and physical biology of how region-specific cell behaviors produce regional tissue morphogenesis, and how these, in turn, are integrated at the level of the embryo. New technical approaches have made it possible more recently, to examine the morphogenesis of the mouse embryo in depth, and to elucidate the underlying cellular mechanisms. This review focuses on recent advances in understanding the cellular basis for the early fundamental events that establish the basic form of the embryo." | ||
Revision as of 07:49, 31 July 2018
Embryology - 20 Apr 2024 Expand to Translate |
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Introduction
Morphodynamics refers to the biomechanical effects involved in development. There are several researchers who continue to build on concepts developed by Blechschmidt and others describing developmental events in terms of the physics involved in stresses and fluid movement within the embryo as important factors involved in establishing embryonic structures.
This page is an attempt to include concepts related to development based upon the physics (stresses, strains, gravity and fluid movement) occuring during growth. In some respects this is in response to the very dominant "molecular" nature of recent studies in comparison to the many other ways of describing developmental events. The two area appear more recently to be converging using new molecular findings to be incorporated or married with the morphodynamic descriptions.
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Morphodynamics <pubmed limit=5>Morphodynamics</pubmed> |
References
- ↑ Labernadie A & Trepat X. (2018). Sticking, steering, squeezing and shearing: cell movements driven by heterotypic mechanical forces. Curr. Opin. Cell Biol. , 54, 57-65. PMID: 29719271 DOI.
- ↑ Sutherland AE. (2016). Tissue morphodynamics shaping the early mouse embryo. Semin. Cell Dev. Biol. , 55, 89-98. PMID: 26820524 DOI.
- ↑ Varner VD, Gleghorn JP, Miller E, Radisky DC & Nelson CM. (2015). Mechanically patterning the embryonic airway epithelium. Proc. Natl. Acad. Sci. U.S.A. , 112, 9230-5. PMID: 26170292 DOI.
- ↑ Imuta Y, Koyama H, Shi D, Eiraku M, Fujimori T & Sasaki H. (2014). Mechanical control of notochord morphogenesis by extra-embryonic tissues in mouse embryos. Mech. Dev. , 132, 44-58. PMID: 24509350 DOI.
- ↑ Kim HY, Varner VD & Nelson CM. (2013). Apical constriction initiates new bud formation during monopodial branching of the embryonic chicken lung. Development , 140, 3146-55. PMID: 23824575 DOI.
Textbooks
Reviews
Heyn R, Makabe S & Motta PM. (2001). Ultrastructural morphodynamics of human Sertoli cells during testicular differentiation. Ital J Anat Embryol , 106, 163-71. PMID: 11732573
Articles
Search PubMed
Search Pubmed: Embryo Morphodynamics | Morphodynamics
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Cite this page: Hill, M.A. (2024, April 20) Embryology Developmental Mechanism - Morphodynamics. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Mechanism_-_Morphodynamics
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G