Developmental Mechanism - Epithelial Mesenchymal Transition: Difference between revisions
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* '''p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes'''<ref><pubmed>21447558</pubmed></ref> "Neural crest development involves epithelial-mesenchymal transition (EMT), during which epithelial cells are converted into individual migratory cells. Notably, the same signaling pathways regulate EMT function during both development and tumor metastasis. p53 plays multiple roles in the prevention of tumor development; however, its precise roles during embryogenesis are less clear. We have investigated the role of p53 in early cranial neural crest (CNC) development in chick and mouse embryos. In the mouse, p53 knockout embryos displayed broad craniofacial defects in skeletal, neuronal and muscle tissues. In the chick, p53 is expressed in CNC progenitors and its expression decreases with their delamination from the neural tube. Stabilization of p53 protein using a pharmacological inhibitor of its negative regulator, MDM2, resulted in reduced SNAIL2 (SLUG) and ETS1 expression, fewer migrating CNC cells and in craniofacial defects." | * '''p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes'''<ref><pubmed>21447558</pubmed></ref> "Neural crest development involves epithelial-mesenchymal transition (EMT), during which epithelial cells are converted into individual migratory cells. Notably, the same signaling pathways regulate EMT function during both development and tumor metastasis. p53 plays multiple roles in the prevention of tumor development; however, its precise roles during embryogenesis are less clear. We have investigated the role of p53 in early cranial neural crest (CNC) development in chick and mouse embryos. In the mouse, p53 knockout embryos displayed broad craniofacial defects in skeletal, neuronal and muscle tissues. In the chick, p53 is expressed in CNC progenitors and its expression decreases with their delamination from the neural tube. Stabilization of p53 protein using a pharmacological inhibitor of its negative regulator, MDM2, resulted in reduced SNAIL2 (SLUG) and ETS1 expression, fewer migrating CNC cells and in craniofacial defects." | ||
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==Mesenchymal-to-Epithelial Transition== | |||
The alternate process involves the conversion of the embryonic connective tissue organization (mesenchyme) to an epithelial organization (epithelium) that can occur during developmental processes. | |||
This process can be seen occurring during early [[Somitogenesis|somitogenesis]]. | |||
A recent paper also suggests that this mechanism occurs in the maternal uterus during endometrial regeneration following decidualization.<ref><pubmed>23216285</pubmed></ref> | |||
== References == | == References == | ||
Revision as of 12:55, 2 January 2013
Introduction
Epithelial cells (organised cellular layer) which loose their organisation and migrate/proliferate as a mesenchymal cells (disorganised cellular layers) are said to have undergone an Epithelial Mesenchymal Transition (EMT).
Mesenchymal cells, connective tissue-like, that have undergone this process may at a later time and under specific signaling can undergo the opposite process, mesenchyme to epithelia. In development, this process can be repeated several times during tissue differentiation.
This process is also studied in carcinogenesis (oncogenesis) or cancer development, where part of this process can be the transformation of an epithelial cell into a mesenchymal cell.[1][2]
Some Recent Findings
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Mesenchymal-to-Epithelial Transition
The alternate process involves the conversion of the embryonic connective tissue organization (mesenchyme) to an epithelial organization (epithelium) that can occur during developmental processes.
This process can be seen occurring during early somitogenesis.
A recent paper also suggests that this mechanism occurs in the maternal uterus during endometrial regeneration following decidualization.[4]
References
Textbooks
Reviews
<pubmed></pubmed>
Articles
Search PubMed
Search Pubmed: Epithelial Mesenchymal Transition
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Cite this page: Hill, M.A. (2024, April 19) Embryology Developmental Mechanism - Epithelial Mesenchymal Transition. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Mechanism_-_Epithelial_Mesenchymal_Transition
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
