Developmental Mechanism - Epithelial Mesenchymal Interaction

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Embryology - 16 Apr 2024 Expand to Translate
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Introduction

Epithelial cells (organised cellular layer) and mesenchymal cells (disorganised cellular layers) or embryonic connective tissue interact together signaling back and forth by secreted signals or contact in the differentiation of many different organs, tissues and structures.

Mechanism - "a process, technique, or system for achieving a result".

Cells organised as a layer (epithelia) and cells organised as a multilayer embryonic connective tissue (mesenchymal) signaling back and forth are key to the of development in many different tissues. For example, in nephron development in the kidney, hair development on the skin and tooth development in the oral epithelium.

In both hair and tooth, an initial epithelial placed is initially formed, that then invaginates into the underlying mesenchyme, and signals for this mesenchyme to then develop.

Some Recent Findings

^[1]

Uterine Gland Development

Uterine adenogenesis is the term used to describe the formation of uterine glands from the epithelial lining of the uterus. In mammals, this development occurs postnatally and has been described as occurring through a 3 step the sequence:

differentiation and budding of the glandular epithelium.
invagination and tubular coiling of the epithelium.
branching of the glandular elements and their expansion throughout the endometrial stroma toward the myometrium.

Epithelial-mesenchymal interaction occurs through Wnt signalling during this process:

Wnt7a - expressed in the luminal epithelium
Wnt5a - expressed in the mesenchyme

In mice, this development sequence occurs between postnatal day (PND) 5 to 7 and involves Wnt up-regulation of Lymphoid Enhancing Factor 1 (Lef1).^[2]

Links: Wnt | Uterus Development

References

↑ <pubmed></pubmed>
↑ Shelton DN, Fornalik H, Neff T, Park SY, Bender D, et al. (2012) The Role of LEF1 in Endometrial Gland Formation and Carcinogenesis. PLoS ONE 7(7): e40312. doi:10.1371/journal.pone.0040312

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Cite this page: Hill, M.A. (2024, April 16) Embryology Developmental Mechanism - Epithelial Mesenchymal Interaction. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Mechanism_-_Epithelial_Mesenchymal_Interaction

What Links Here?

[1] <pubmed></pubmed>

[2] Shelton DN, Fornalik H, Neff T, Park SY, Bender D, et al. (2012) The Role of LEF1 in Endometrial Gland Formation and Carcinogenesis. PLoS ONE 7(7): e40312. doi:10.1371/journal.pone.0040312

[1]

[2]