Developmental Mechanism - Epithelial Invagination
|Embryology - 29 Feb 2020 Expand to Translate|
|Google Translate - select your language from the list shown below (this will open a new external page)|
العربية | català | 中文 | 中國傳統的 | français | Deutsche | עִברִית | हिंदी | bahasa Indonesia | italiano | 日本語 | 한국어 | မြန်မာ | Pilipino | Polskie | português | ਪੰਜਾਬੀ ਦੇ | Română | русский | Español | Swahili | Svensk | ไทย | Türkçe | اردو | ייִדיש | Tiếng Việt These external translations are automated and may not be accurate. (More? About Translations)
Epithelia during development often undergo folding or invagination. In some cases the epithelial cells are eventually "pinched off" fron the existing epithelia to form a distinct structure, such as a tube or vesicle. For example this process occurs in neural tube formation, sensory placode (otic and optic vesicles). Changes in cell shape require changes in the actin cytoskeleton and recent researh has shown Rho1 a small GTPase of the Rho subfamily (Rho, Rac and Cdc42) which acts as regulatory switch for actin cytoskeleton is activated in epithelial cells for invagination process initiation.
Some Recent Findings
|More recent papers|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
Search term: Epithelial Invagination
<pubmed limit=5>Epithelial Invagination</pubmed>
Neural Plate to Neural Groove
In week 3 (GA week 5) of human development, the ectodermal neural plate invaginated to form the neural groove. This is the first step in converting an epithelial sheet into an epithelial tube that will form the central nervous system.
Dorsal view of the early human embryo (stage 10) showing the neural plate folding to form an open groove.
- Links: Neural System Development
Otic Placode to Otic Vesicle
In week 4 (GA week 6) of human development, on the embryo head region surface ectoderm specialised "patches" (placodes) form associated with later sensory and endocrine development. The first to appear are the paired otic placodes, forming behind the second pharyngeal arch, that invaginate and are eventually lost from the surface. These placodes will form the structures of the inner ear. Other sensory placodes, nasal and optic, can be seen slightly later.
Dorsal view of the early human embryo (stage 11) showing the surface ectoderm otic placode folding to form an indentation on the embryo surface.
Search Pubmed: Endocrine Development
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2020, February 29) Embryology Developmental Mechanism - Epithelial Invagination. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Mechanism_-_Epithelial_Invagination
- © Dr Mark Hill 2020, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G