Developmental Mechanism - Cell Migration
Embryology - 24 Apr 2024 Expand to Translate |
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Introduction
The process of cell migration occurs at different stages throughout embryonic development and involves other developmental mechanisms. The first key migration occurs during Gastrulation. Later key migratory events also occur during somite dispersion and neural crest migration.
Some Recent Findings
"Head development in vertebrates proceeds through a series of elaborate patterning mechanisms and cell-cell interactions involving cephalic neural crest cells (CNCC). These cells undergo extensive migration along stereotypical paths after their separation from the dorsal margins of the neural tube and they give rise to most of the craniofacial skeleton. Here, we report that the silencing of the LKB1 tumor suppressor affects the delamination of pre-migratory CNCC from the neural primordium as well as their polarization and survival, thus resulting in severe facial and brain defects. We further show that LKB1-mediated effects on the development of CNCC involve the sequential activation of the AMP-activated protein kinase (AMPK), the Rho-dependent kinase (ROCK) and the actin-based motor protein myosin II. Collectively, these results establish that the complex morphogenetic processes governing head formation critically depends on the activation of the LKB1 signaling network in CNCC."
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Developmental Cell Migration <pubmed limit=5>Developmental Cell Migration</pubmed> Search term: Neural Crest Cell Migration <pubmed limit=5>Neural Crest Cell Migration</pubmed> |
Neural Crest Development
- Links: Neural Crest Development
References
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<pubmed></pubmed> <pubmed></pubmed> <pubmed>26783298</pubmed> <pubmed>25733144</pubmed> <pubmed>19914236</pubmed>
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Search Pubmed: Epithelial Mesenchymal Interaction
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Cite this page: Hill, M.A. (2024, April 24) Embryology Developmental Mechanism - Cell Migration. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Mechanism_-_Cell_Migration
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G